KEGG   Homo sapiens (human): 51135
Entry
51135             CDS       T01001                                 
Symbol
IRAK4, IMD67, IPD1, IRAK-4, NY-REN-64, REN64
Name
(RefSeq) interleukin 1 receptor associated kinase 4
  KO
K04733  interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04936  Alcoholic liver disease
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
nt06183  Yersinia
nt06211  Other MAPK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06526  MAPK signaling
  Element
N00186  IL1-IL1R-p38 signaling pathway
N00188  IL1-IL1R-JNK signaling pathway
N00435  TLR1/2/4-NFKB signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00690  TLR7/9-IRF7 signaling pathway
N01543  TLR7/8/9-IRF5 signaling pathway
N01566  TLR5-NFKB signaling pathway
Disease
H00096  Defects of toll-like receptor signaling
Drug target
Emavusertib (DG03236): D12411 D12412 D12532 D12533 D12538 D12539
Zimlovisertib: D12167
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    51135 (IRAK4)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    51135 (IRAK4)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    51135 (IRAK4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    51135 (IRAK4)
   05161 Hepatitis B
    51135 (IRAK4)
   05171 Coronavirus disease - COVID-19
    51135 (IRAK4)
   05164 Influenza A
    51135 (IRAK4)
   05162 Measles
    51135 (IRAK4)
   05169 Epstein-Barr virus infection
    51135 (IRAK4)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    51135 (IRAK4)
   05135 Yersinia infection
    51135 (IRAK4)
   05133 Pertussis
    51135 (IRAK4)
   05152 Tuberculosis
    51135 (IRAK4)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    51135 (IRAK4)
   05140 Leishmaniasis
    51135 (IRAK4)
   05142 Chagas disease
    51135 (IRAK4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    51135 (IRAK4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    51135 (IRAK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    51135 (IRAK4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     51135 (IRAK4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  IRAK family
   51135 (IRAK4)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Pkinase_fungal Haspin_kinase Death RecA_C
Other DBs
NCBI-GeneID: 51135
NCBI-ProteinID: NP_001107654
OMIM: 606883
HGNC: 17967
Ensembl: ENSG00000198001
UniProt: Q9NWZ3 Q69FE3 B4E359
Structure
LinkDB
Position
12:43758951..43789541
AA seq 460 aa
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
NT seq 1383 nt   +upstreamnt  +downstreamnt
atgaacaaacccataacaccatcaacatatgtgcgctgcctcaatgttggactaattagg
aagctgtcagattttattgatcctcaagaaggatggaagaagttagctgtagctattaaa
aaaccatctggtgatgatagatacaatcagtttcacataaggagatttgaagcattactt
caaactggaaaaagtcccacttctgaattactgtttgactggggcaccacaaattgcaca
gttggtgatcttgtggatcttttgatccaaaatgaattttttgctcctgcgagtcttttg
ctcccagatgctgttcccaaaactgctaatacactaccttctaaagaagctataacagtt
cagcaaaaacagatgcctttctgtgacaaagacaggacattgatgacacctgtgcagaat
cttgaacaaagctatatgccacctgactcctcaagtccagaaaataaaagtttagaagtt
agtgatacacgttttcacagtttttcattttatgaattgaagaatgtcacaaataacttt
gatgaacgacccatttctgttggtggtaataaaatgggagagggaggatttggagttgta
tataaaggctacgtaaataacacaactgtggcagtgaagaagcttgcagcaatggttgac
attactactgaagaactgaaacagcagtttgatcaagaaataaaagtaatggcaaagtgt
caacatgaaaacttagtagaactacttggtttctcaagtgatggagatgacctctgctta
gtatatgtttacatgcctaatggttcattgctagacagactctcttgcttggatggtact
ccaccactttcttggcacatgagatgcaagattgctcagggtgcagctaatggcatcaat
tttctacatgaaaatcatcatattcatagagatattaaaagtgcaaatatcttactggat
gaagcttttactgctaaaatatctgactttggccttgcacgggcttctgagaagtttgcc
cagacagtcatgactagcagaattgtgggaacaacagcttatatggcaccagaagctttg
cgtggagaaataacacccaaatctgatatttacagctttggtgtggttttactagaaata
ataactggacttccagctgtggatgaacaccgtgaacctcagttattgctagatattaaa
gaagaaattgaagatgaagaaaagacaattgaagattatattgataaaaagatgaatgat
gctgattccacttcagttgaagctatgtactctgttgctagtcaatgtctgcatgaaaag
aaaaataagagaccagacattaagaaggttcaacagctgctgcaagagatgacagcttct
taa

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