KEGG   Homo sapiens (human): 4615
Entry
4615              CDS       T01001                                 
Symbol
MYD88, IMD68, MYD88D, WM1
Name
(RefSeq) MYD88 innate immune signal transduction adaptor
  KO
K04729  myeloid differentiation primary response protein MyD88
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04936  Alcoholic liver disease
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05143  African trypanosomiasis
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
nt06183  Yersinia
nt06211  Other MAPK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06526  MAPK signaling
  Element
N00186  IL1-IL1R-p38 signaling pathway
N00188  IL1-IL1R-JNK signaling pathway
N00435  TLR1/2/4-NFKB signaling pathway
N00438  TLR2/4-MAPK signaling pathway
N00549  HBV HBeAg to TLR2/4-NFKB signaling pathway
N00561  HSV ICP0 to TLR2/4-NFKB signaling pathway
N00690  TLR7/9-IRF7 signaling pathway
N01543  TLR7/8/9-IRF5 signaling pathway
N01566  TLR5-NFKB signaling pathway
Disease
H00721  Pyogenic bacterial infections, recurrent, due to MYD88 deficiency
H02424  Primary central nervous system lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    4615 (MYD88)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    4615 (MYD88)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    4615 (MYD88)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    4615 (MYD88)
   05161 Hepatitis B
    4615 (MYD88)
   05171 Coronavirus disease - COVID-19
    4615 (MYD88)
   05164 Influenza A
    4615 (MYD88)
   05162 Measles
    4615 (MYD88)
   05169 Epstein-Barr virus infection
    4615 (MYD88)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    4615 (MYD88)
   05131 Shigellosis
    4615 (MYD88)
   05135 Yersinia infection
    4615 (MYD88)
   05133 Pertussis
    4615 (MYD88)
   05134 Legionellosis
    4615 (MYD88)
   05152 Tuberculosis
    4615 (MYD88)
  09174 Infectious disease: parasitic
   05144 Malaria
    4615 (MYD88)
   05145 Toxoplasmosis
    4615 (MYD88)
   05140 Leishmaniasis
    4615 (MYD88)
   05142 Chagas disease
    4615 (MYD88)
   05143 African trypanosomiasis
    4615 (MYD88)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    4615 (MYD88)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    4615 (MYD88)
SSDB
Motif
Pfam: Death TIR_2 TIR
Other DBs
NCBI-GeneID: 4615
NCBI-ProteinID: NP_002459
OMIM: 602170
HGNC: 7562
Ensembl: ENSG00000172936
UniProt: Q99836
Structure
LinkDB
Position
3:38138661..38143022
AA seq 296 aa
MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLE
IRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQ
QQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIR
QLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFA
LSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP
NT seq 891 nt   +upstreamnt  +downstreamnt
atggctgcaggaggtcccggcgcggggtctgcggccccggtctcctccacatcctccctt
cccctggctgctctcaacatgcgagtgcggcgccgcctgtctctgttcttgaacgtgcgg
acacaggtggcggccgactggaccgcgctggcggaggagatggactttgagtacttggag
atccggcaactggagacacaagcggaccccactggcaggctgctggacgcctggcaggga
cgccctggcgcctctgtaggccgactgctcgagctgcttaccaagctgggccgcgacgac
gtgctgctggagctgggacccagcattgaggaggattgccaaaagtatatcttgaagcag
cagcaggaggaggctgagaagcctttacaggtggccgctgtagacagcagtgtcccacgg
acagcagagctggcgggcatcaccacacttgatgaccccctggggcatatgcctgagcgt
ttcgatgccttcatctgctattgccccagcgacatccagtttgtgcaggagatgatccgg
caactggaacagacaaactatcgactgaagttgtgtgtgtctgaccgcgatgtcctgcct
ggcacctgtgtctggtctattgctagtgagctcatcgaaaagaggtgccgccggatggtg
gtggttgtctctgatgattacctgcagagcaaggaatgtgacttccagaccaaatttgca
ctcagcctctctccaggtgcccatcagaagcgactgatccccatcaagtacaaggcaatg
aagaaagagttccccagcatcctgaggttcatcactgtctgcgactacaccaacccctgc
accaaatcttggttctggactcgccttgccaaggccttgtccctgccctga

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