| Entry |
|
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| Name |
TGFA-overexpression to PI3K signaling pathway
|
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| Definition |
TGFA* -> EGFR -> PI3K -> PIP3 -> AKT |
|---|
| Expanded |
7039v1 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) |
|---|
| Class |
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| Type |
Variant
|
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| Pathway |
|
|---|
| Disease |
| H00048 | Hepatocellular carcinoma |
|
|---|
| Gene |
| 7039 | TGFA; transforming growth factor alpha |
| 1956 | EGFR; epidermal growth factor receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
|
|---|
| Variant |
7039v1 (TGFA*) TGFA overexpression
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Yarden Y, Sliwkowski MX. |
|---|
| Title |
Untangling the ErbB signalling network. |
|---|
| Journal |
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| Reference |
|
|---|
| Authors |
Hutchinson RA, Adams RA, McArt DG, Salto-Tellez M, Jasani B, Hamilton PW |
|---|
| Title |
Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Whittaker S, Marais R, Zhu AX |
|---|
| Title |
The role of signaling pathways in the development and treatment of hepatocellular carcinoma. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM. |
|---|
| Title |
Genomics and signaling pathways in hepatocellular carcinoma. |
|---|
| Journal |
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| LinkDB |
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