KEGG   NETWORK: N00234
Entry
N00234                      Network                                
Name
IGF2-IGF1R-PI3K signaling pathway
Definition
IGF2 -> IGF1R -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
3481 -> 3480 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06263 Hepatocellular carcinoma
nt06214 PI3K signaling (cancer)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
3481  IGF2; insulin like growth factor 2
3480  IGF1R; insulin like growth factor 1 receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:25362932
  Authors
Aaltonen KE, Rosendahl AH, Olsson H, Malmstrom P, Hartman L, Ferno M
  Title
Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer.
  Journal
BMC Cancer 14:794 (2014)
DOI:10.1186/1471-2407-14-794
Reference
PMID:26429980
  Authors
Iams WT, Lovly CM
  Title
Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade.
  Journal
Clin Cancer Res 21:4270-7 (2015)
DOI:10.1158/1078-0432.CCR-14-2518
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