| Entry |
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| Name |
Mutation-inactivated AXIN to Wnt signaling pathway
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| Definition |
(GSK3B+APC) // AXIN* // CTNNB1 -> TCF/LEF => (MYC,CCND1) |
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| Expanded |
(2932+324) // 8312v1 // 1499 -> (6932,83439,6934,51176) => (4609,595) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00048 | Hepatocellular carcinoma |
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| Gene |
| 2932 | GSK3B; glycogen synthase kinase 3 beta |
| 324 | APC; APC, WNT signaling pathway regulator |
| 1499 | CTNNB1; catenin beta 1 |
| 6932 | TCF7; transcription factor 7 |
| 83439 | TCF7L1; transcription factor 7 like 1 |
| 6934 | TCF7L2; transcription factor 7 like 2 |
| 51176 | LEF1; lymphoid enhancer binding factor 1 |
| 4609 | MYC; MYC proto-oncogene, bHLH transcription factor |
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| Variant |
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| Reference |
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| Authors |
Polakis P |
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| Title |
Wnt signaling in cancer. |
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| Journal |
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| Reference |
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| Authors |
Salahshor S, Woodgett JR |
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| Title |
The links between axin and carcinogenesis. |
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| Journal |
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| Reference |
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| Authors |
Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W |
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| Title |
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. |
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| Journal |
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| Reference |
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| Authors |
Mazzoni SM, Fearon ER |
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| Title |
AXIN1 and AXIN2 variants in gastrointestinal cancers. |
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| Journal |
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| Reference |
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| Authors |
Kumar M, Zhao X, Wang XW |
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| Title |
Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine? |
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| Journal |
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| Reference |
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| Authors |
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM. |
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| Title |
Genomics and signaling pathways in hepatocellular carcinoma. |
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| Journal |
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| LinkDB |
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