KEGG   NETWORK: N00258
Entry
N00258                      Network                                
Name
Mutation-inactivated CDH1 to beta-catenin signaling pathway
Definition
CDH1* // CTNNB1 -> TCF/LEF => (MYC,CCND1)
  Expanded
999v2 // 1499 -> (6932,83439,6934,51176) => (4609,595)
Class
nt06261 Gastric cancer
nt06215 WNT signaling (cancer)
Type
Variant
Pathway
hsa05226  Gastric cancer
Disease
H00018  Gastric cancer
Gene
999  CDH1; cadherin 1
1499  CTNNB1; catenin beta 1
6932  TCF7; transcription factor 7
83439  TCF7L1; transcription factor 7 like 1
6934  TCF7L2; transcription factor 7 like 2
51176  LEF1; lymphoid enhancer binding factor 1
4609  MYC; MYC proto-oncogene, bHLH transcription factor
595  CCND1; cyclin D1
Variant
999v2 (CDH1*)  CDH1 mutation
Reference
PMID:16154715
  Authors
Stock M, Otto F
  Title
Gene deregulation in gastric cancer.
  Journal
Gene 360:1-19 (2005)
DOI:10.1016/j.gene.2005.06.026
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