KEGG   NETWORK: N00281
Entry
N00281                      Network                                
Name
EGF-overexpression to PI3K signaling pathway
Definition
EGF* -> EGFR -> PI3K -> PIP3 -> AKT
  Expanded
1950v1 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06260 Colorectal cancer
nt06214 PI3K signaling (cancer)
Type
Variant
Pathway
hsa05210  Colorectal cancer
Disease
H00020  Colorectal cancer
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Variant
1950v1 (EGF*)  EGF overexpression
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24213116
  Authors
Wang D, Xia D, Dubois RN
  Title
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer.
  Journal
Cancers (Basel) 3:3894-908 (2011)
DOI:10.3390/cancers3043894
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