KEGG   NETWORK: N00317
Entry
N00317                      Network                                

Name
AhR signaling pathway
Definition
KA -> (AHR+ARNT) => (IL6,IL22,PTGS2,VEGFA,CYP1A1,CYP1B1)
  Expanded
C01717 -> (196+405) => (3569,50616,5743,7422,1543,1545)
Class
nt06227 Nuclear receptor signaling
nt06360 Cushing syndrome
Type
Reference
Gene
196  AHR; aryl hydrocarbon receptor
405  ARNT; aryl hydrocarbon receptor nuclear translocator
3569  IL6; interleukin 6
50616  IL22; interleukin 22
5743  PTGS2; prostaglandin-endoperoxide synthase 2
7422  VEGFA; vascular endothelial growth factor A
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1
1545  CYP1B1; cytochrome P450 family 1 subfamily B member 1
Metabolite
C01717  4-Hydroxy-2-quinolinecarboxylic acid
Reference
  Authors
Hubbard TD, Murray IA, Perdew GH
  Title
Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation.
  Journal
Drug Metab Dispos 43:1522-35 (2015)
DOI:10.1124/dmd.115.064246
Reference
  Authors
Gao J, Xu K, Liu H, Liu G, Bai M, Peng C, Li T, Yin Y
  Title
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism.
  Journal
Front Cell Infect Microbiol 8:13 (2018)
DOI:10.3389/fcimb.2018.00013
Reference
  Authors
Larigot L, Juricek L, Dairou J, Coumoul X
  Title
AhR signaling pathways and regulatory functions.
  Journal
Biochim Open 7:1-9 (2018)
DOI:10.1016/j.biopen.2018.05.001
Reference
  Authors
Bock KW
  Title
Aryl hydrocarbon receptor (AHR), integrating energy metabolism and microbial or obesity-mediated inflammation.
  Journal
Biochem Pharmacol 184:114346 (2021)
DOI:10.1016/j.bcp.2020.114346
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