Homo sapiens (human): 2353
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Entry
2353 CDS
T01001
Symbol
FOS, AP-1, C-FOS, p55
Name
(RefSeq) Fos proto-oncogene, AP-1 transcription factor subunit
KO
K04379
proto-oncogene protein c-fos
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04010
MAPK signaling pathway
hsa04024
cAMP signaling pathway
hsa04210
Apoptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa04668
TNF signaling pathway
hsa04713
Circadian entrainment
hsa04725
Cholinergic synapse
hsa04728
Dopaminergic synapse
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04921
Oxytocin signaling pathway
hsa04926
Relaxin signaling pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa04932
Non-alcoholic fatty liver disease
hsa04935
Growth hormone synthesis, secretion and action
hsa05031
Amphetamine addiction
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05161
Hepatitis B
hsa05162
Measles
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05210
Colorectal cancer
hsa05224
Breast cancer
hsa05231
Choline metabolism in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05323
Rheumatoid arthritis
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06210
ERK signaling (cancer)
nt06211
Other MAPK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06223
TNF signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06461
Huntington disease
nt06516
TNF signaling
nt06517
TLR signaling
nt06526
MAPK signaling
Element
N00188
IL1-IL1R-JNK signaling pathway
N00438
TLR2/4-MAPK signaling pathway
N00446
TNF-JNK signaling pathway
N00447
HIV Vpr/Tat to TNF-JNK signaling pathway
N00509
HTLV-1 Tax to SRF-mediated transcription
N00545
HBV HBx to ERK signaling pathway
N01344
NNK/NNN to RAS-ERK signaling pathway
N01350
NNK/NNN to PI3K signaling pathway
N01353
E2 to RAS-ERK signaling pathway
N01407
Metals to JNK signaling pathway
N01408
Metals to RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
2353 (FOS)
04024 cAMP signaling pathway
2353 (FOS)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
2353 (FOS)
04660 T cell receptor signaling pathway
2353 (FOS)
04658 Th1 and Th2 cell differentiation
2353 (FOS)
04659 Th17 cell differentiation
2353 (FOS)
04657 IL-17 signaling pathway
2353 (FOS)
04662 B cell receptor signaling pathway
2353 (FOS)
09152 Endocrine system
04915 Estrogen signaling pathway
2353 (FOS)
04917 Prolactin signaling pathway
2353 (FOS)
04921 Oxytocin signaling pathway
2353 (FOS)
04926 Relaxin signaling pathway
2353 (FOS)
04935 Growth hormone synthesis, secretion and action
2353 (FOS)
04928 Parathyroid hormone synthesis, secretion and action
2353 (FOS)
09156 Nervous system
04725 Cholinergic synapse
2353 (FOS)
04728 Dopaminergic synapse
2353 (FOS)
09158 Development and regeneration
04380 Osteoclast differentiation
2353 (FOS)
09159 Environmental adaptation
04713 Circadian entrainment
2353 (FOS)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2353 (FOS)
05207 Chemical carcinogenesis - receptor activation
2353 (FOS)
05208 Chemical carcinogenesis - reactive oxygen species
2353 (FOS)
05231 Choline metabolism in cancer
2353 (FOS)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
2353 (FOS)
09162 Cancer: specific types
05210 Colorectal cancer
2353 (FOS)
05224 Breast cancer
2353 (FOS)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
2353 (FOS)
05170 Human immunodeficiency virus 1 infection
2353 (FOS)
05161 Hepatitis B
2353 (FOS)
05171 Coronavirus disease - COVID-19
2353 (FOS)
05162 Measles
2353 (FOS)
05167 Kaposi sarcoma-associated herpesvirus infection
2353 (FOS)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
2353 (FOS)
05135 Yersinia infection
2353 (FOS)
05133 Pertussis
2353 (FOS)
09174 Infectious disease: parasitic
05140 Leishmaniasis
2353 (FOS)
05142 Chagas disease
2353 (FOS)
09163 Immune disease
05323 Rheumatoid arthritis
2353 (FOS)
09165 Substance dependence
05031 Amphetamine addiction
2353 (FOS)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
2353 (FOS)
05418 Fluid shear stress and atherosclerosis
2353 (FOS)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
2353 (FOS)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
2353 (FOS)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
2353 (FOS)
04131 Membrane trafficking [BR:
hsa04131
]
2353 (FOS)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Basic leucine zipper (bZIP)
AP-1(-like) components, Fos
2353 (FOS)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Chaperone mediated autophagy (CMA)
Selective cargos
2353 (FOS)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
bZIP_1
bZIP_2
bZIP_Maf
MIC19_MIC25
DUF3450
HALZ
Macoilin
Motif
Other DBs
NCBI-GeneID:
2353
NCBI-ProteinID:
NP_005243
OMIM:
164810
HGNC:
3796
Ensembl:
ENSG00000170345
UniProt:
P01100
Q6FG41
Structure
PDB
PDBj
LinkDB
All DBs
Position
14:75278828..75282230
Genome browser
AA seq
380 aa
AA seq
DB search
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
NT seq
1143 nt
NT seq
+upstream
nt +downstream
nt
atgatgttctcgggcttcaacgcagactacgaggcgtcatcctcccgctgcagcagcgcg
tccccggccggggatagcctctcttactaccactcacccgcagactccttctccagcatg
ggctcgcctgtcaacgcgcaggacttctgcacggacctggccgtctccagtgccaacttc
attcccacggtcactgccatctcgaccagtccggacctgcagtggctggtgcagcccgcc
ctcgtctcctccgtggccccatcgcagaccagagcccctcaccctttcggagtccccgcc
ccctccgctggggcttactccagggctggcgttgtgaagaccatgacaggaggccgagcg
cagagcattggcaggaggggcaaggtggaacagttatctccagaagaagaagagaaaagg
agaatccgaagggaaaggaataagatggctgcagccaaatgccgcaaccggaggagggag
ctgactgatacactccaagcggagacagaccaactagaagatgagaagtctgctttgcag
accgagattgccaacctgctgaaggagaaggaaaaactagagttcatcctggcagctcac
cgacctgcctgcaagatccctgatgacctgggcttcccagaagagatgtctgtggcttcc
cttgatctgactgggggcctgccagaggttgccaccccggagtctgaggaggccttcacc
ctgcctctcctcaatgaccctgagcccaagccctcagtggaacctgtcaagagcatcagc
agcatggagctgaagaccgagccctttgatgacttcctgttcccagcatcatccaggccc
agtggctctgagacagcccgctccgtgccagacatggacctatctgggtccttctatgca
gcagactgggagcctctgcacagtggctccctggggatggggcccatggccacagagctg
gagcccctgtgcactccggtggtcacctgtactcccagctgcactgcttacacgtcttcc
ttcgtcttcacctaccccgaggctgactccttccccagctgtgcagctgcccaccgcaag
ggcagcagcagcaatgagccttcctctgactcgctcagctcacccacgctgctggccctg
tga
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