KEGG   NETWORK: N00506
Entry
N00506                      Network                                
Name
HTLV-1 Tax to CD40-NFKB signaling pathway
Definition
TAX == IKBKG -> IKKA -> (NFKB2+RELB)
  Expanded
K21857 == 8517 -> 1147 -> (4791+5971)
Class
nt06516 TNF signaling
nt06223 TNF signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
4791  NFKB2; nuclear factor kappa B subunit 2
5971  RELB; RELB proto-oncogene, NF-kB subunit
Perturbant
K21857 (TAX)  tax; HTLV protein Tax-1
Reference
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
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