| Entry |
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| Name |
Mutation-activated EGFR to PI3K signaling pathway
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| Definition |
EGFR* -> PI3K -> PIP3 -> AKT -| BAD |
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| Expanded |
1956v5 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 1956 | EGFR; epidermal growth factor receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
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| Variant |
1956v5 (EGFR*) EGFR mutation in glioblastoma
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Hatanpaa KJ, Burma S, Zhao D, Habib AA |
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| Title |
Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance. |
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| Journal |
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| Reference |
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| Authors |
Xu H, Zong H, Ma C, Ming X, Shang M, Li K, He X, Du H, Cao L |
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| Title |
Epidermal growth factor receptor in glioblastoma. |
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| Journal |
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| Reference |
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| Authors |
An Z, Aksoy O, Zheng T, Fan QW, Weiss WA |
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| Title |
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies. |
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| Journal |
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| LinkDB |
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