| Entry |
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| Name |
EGF-EGFR-RAS-JNK signaling pathway
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| Definition |
EGF -> EGFR -> GRB2 -> SOS -> RAS -> MEKK1 -> MKK4 -> JNK |
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| Expanded |
1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> 4214 -> 6416 -> (5599,5601,5602) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 1950 | EGF; epidermal growth factor |
| 1956 | EGFR; epidermal growth factor receptor |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 4214 | MAP3K1; mitogen-activated protein kinase kinase kinase 1 |
| 6416 | MAP2K4; mitogen-activated protein kinase kinase 4 |
| 5599 | MAPK8; mitogen-activated protein kinase 8 |
| 5601 | MAPK9; mitogen-activated protein kinase 9 |
| 5602 | MAPK10; mitogen-activated protein kinase 10 |
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| Reference |
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| Authors |
Haddad RI, Shin DM |
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| Title |
Recent advances in head and neck cancer. |
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| Journal |
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| Reference |
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| Authors |
Reuter CW, Morgan MA, Bergmann L |
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| Title |
Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? |
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| Journal |
Blood 96:1655-69 (2000) |
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| Reference |
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| Authors |
Verheij M, Ruiter GA, Zerp SF, van Blitterswijk WJ, Fuks Z, Haimovitz-Friedman A, Bartelink H |
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| Title |
The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis. |
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| Journal |
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| Reference |
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| Authors |
Zhao HF, Wang J, Tony To SS |
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| Title |
The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review). |
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| Journal |
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| LinkDB |
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