KEGG   NETWORK: N00553
Entry
N00553                      Network                                

Name
TLR4-IRF3/7 signaling pathway
Definition
TLR4 -> TICAM2 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> (IRF3,IRF7) => IFNB1
  Expanded
7099 -> 353376 -> 148022 -> 7187 -> (9641+29110) -> (3661,3665) => 3456
Class
nt06263 Hepatocellular carcinoma
nt06121 TLR signaling (viruses and bacteria)
nt06162 Hepatitis B virus (HBV)
Type
Reference
Pathway
hsa04620  Toll-like receptor signaling pathway
Gene
7099  TLR4; toll like receptor 4
353376  TICAM2; toll like receptor adaptor molecule 2
148022  TICAM1; toll like receptor adaptor molecule 1
7187  TRAF3; TNF receptor associated factor 3
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
29110  TBK1; TANK binding kinase 1
3661  IRF3; interferon regulatory factor 3
3665  IRF7; interferon regulatory factor 7
3456  IFNB1; interferon beta 1
Reference
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
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