KEGG   NETWORK: N00584
Entry
N00584                      Network                                

Name
HSV US3 to MTOR signaling pathway
Definition
US3 -| (TSC1+TSC2) -| RHEB -> MTOR -| EIF4EBP1
  Expanded
K19439 -| (7248+7249) -| 6009 -> 2475 -| 1978
Class
nt06114 PI3K signaling (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
7248  TSC1; TSC complex subunit 1
7249  TSC2; TSC complex subunit 2
6009  RHEB; Ras homolog, mTORC1 binding
2475  MTOR; mechanistic target of rapamycin kinase
1978  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
Perturbant
K19439 (US3)  US3; Simplexvirus serine/threonine-protein kinase US3
Reference
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
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