Homo sapiens (human): 7248
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Entry
7248 CDS
T01001
Symbol
TSC1, LAM, TSC
Name
(RefSeq) TSC complex subunit 1
KO
K07206
tuberous sclerosis 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04072
Phospholipase D signaling pathway
hsa04140
Autophagy - animal
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04211
Longevity regulating pathway
hsa04218
Cellular senescence
hsa04714
Thermogenesis
hsa04910
Insulin signaling pathway
hsa05163
Human cytomegalovirus infection
hsa05165
Human papillomavirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05231
Choline metabolism in cancer
Network
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06462
Spinocerebellar ataxia
nt06522
mTOR signaling
Element
N00357
HPV E6 to MTOR signaling pathway
N00388
HCMV UL38 to MTOR signaling pathway
N00582
IGF-IGF1R-PI3K signaling pathway
N00584
HSV US3 to MTOR signaling pathway
N00963
RELN-VLDLR-PI3K signaling pathway
N01575
TSC1/2-mTORC1 signaling pathway
N01576
STRAD/STK11- TSC signaling pathway
Disease
H00896
Lymphangioleiomyomatosis
H00915
Tuberous sclerosis complex
H01251
Focal cortical dysplasia of Taylor
H01691
Renal angiomyolipoma
H01692
Subependymal giant cell astrocytoma
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04072 Phospholipase D signaling pathway
7248 (TSC1)
04151 PI3K-Akt signaling pathway
7248 (TSC1)
04152 AMPK signaling pathway
7248 (TSC1)
04150 mTOR signaling pathway
7248 (TSC1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
7248 (TSC1)
09150 Organismal Systems
09149 Aging
04211 Longevity regulating pathway
7248 (TSC1)
09159 Environmental adaptation
04714 Thermogenesis
7248 (TSC1)
09160 Human Diseases
09161 Cancer: overview
05231 Choline metabolism in cancer
7248 (TSC1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
7248 (TSC1)
05165 Human papillomavirus infection
7248 (TSC1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Hamartin
Motif
Other DBs
NCBI-GeneID:
7248
NCBI-ProteinID:
NP_000359
OMIM:
605284
HGNC:
12362
Ensembl:
ENSG00000165699
UniProt:
Q92574
Q86WV8
X5D9D2
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:complement(132891349..132945378)
Genome browser
AA seq
1164 aa
AA seq
DB search
MAQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYYLETSSQPALHI
LTTLQEPHDKHLLDRINEYVGKAATRLSILSLLGHVIRLQPSWKHKLSQAPLLPSLLKCL
KMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVAEVYLVHL
HASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDH
ELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADT
QNSYGCATSTPYSTSRLMLLNMPGQLPQTLSSPSTRLITEPPQATLWSPSMVCGMTTPPT
SPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPLCHSDDYVHISLPQATVTPPR
KEERMDSARPCLHRQHHLLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEA
AISRELSEITTAEAEPVVPRGGFDSPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSL
DKLGPDTPKQAFTPIDLPCGSADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQ
PPPYDHLFEVALPKTAHHFVIRKTEELLKKAKGNTEEDGVPSTSPMEVLDRLIQQGADAH
SKELNKLPLPSKSVDWTHFGGSPPSDEIRTLRDQLLLLHNQLLYERFKRQQHALRNRRLL
RKVIKAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYNQLQEQRDTMVTKLHSQIR
QLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSNSES
VQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQ
RLDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFEL
EILDLYGRLEKDGLLKKLEEEKAEAAEAAEERLDCCNDGCSDSMVGHNEEASGHNGETKT
PRPSSARGSSGSRGGGGSSSSSSELSTPEKPPHQRAGPFSSRWETTMGEASASIPTTVGS
LPSSKSFLGMKARELFRNKSESQCDEDGMTSSLSESLKTELGKDLGVEAKIPLNLDGPHP
SPPTPDSVGQLHIMDYNETHHEHS
NT seq
3495 nt
NT seq
+upstream
nt +downstream
nt
atggcccaacaagcaaatgtcggggagcttcttgccatgctggactcccccatgctgggt
gtgcgggacgacgtgacagctgtctttaaagagaacctcaattctgaccgtggccctatg
cttgtaaacaccttggtggattattacctggaaaccagctctcagccggcattgcacatc
ctgaccaccttgcaagagccacatgacaagcacctcttggacaggattaacgaatatgtg
ggcaaagccgccactcgtttatccatcctctcgttactgggtcatgtcataagactgcag
ccatcttggaagcataagctctctcaagcacctcttttgccttctttactaaaatgtctc
aagatggacactgacgtcgttgtcctcacaacaggcgtcttggtgttgataaccatgcta
ccaatgattccacagtctgggaaacagcatcttcttgatttctttgacatttttggccgt
ctgtcatcatggtgcctgaagaaaccaggccacgtggcggaagtctatctcgtccatctc
catgccagtgtgtacgcactctttcatcgcctttatggaatgtacccttgcaacttcgtc
tcctttttgcgttctcattacagtatgaaagaaaacctggagacttttgaagaagtggtc
aagccaatgatggagcatgtgcgaattcatccggaattagtgactggatccaaggaccat
gaactggaccctcgaaggtggaagagattagaaactcatgatgttgtgatcgagtgtgcc
aaaatctctctggatcccacagaagcctcatatgaagatggctattctgtgtctcaccaa
atctcagcccgctttcctcatcgttcagccgatgtcaccaccagcccttatgctgacaca
cagaatagctatgggtgtgctacttctaccccttactccacgtctcggctgatgttgtta
aatatgccagggcagctacctcagactctgagttccccatcgacacggctgataactgaa
ccaccacaagctactctttggagcccatctatggtttgtggtatgaccactcctccaact
tctcctggaaatgtcccacctgatctgtcacacccttacagtaaagtctttggtacaact
gcaggtggaaaaggaactcctctgggaaccccagcaacctctcctcctccagccccactc
tgtcattcggatgactacgtgcacatttcactcccccaggccacagtcacaccccccagg
aaggaagagagaatggattctgcaagaccatgtctacacagacaacaccatcttctgaat
gacagaggatcagaagagccacctggcagcaaaggttctgtcactctaagtgatcttcca
gggtttttaggtgatctggcctctgaagaagatagtattgaaaaagataaagaagaagct
gcaatatctagagaactttctgagatcaccacagcagaggcagagcctgtggttcctcga
ggaggctttgactctcccttttaccgagacagtctcccaggttctcagcggaagacccac
tcggcagcctccagttctcagggcgccagcgtgaaccctgagcctttacactcctccctg
gacaagcttgggcctgacacaccaaagcaagcctttactcccatagacctgccctgcggc
agtgctgatgaaagccctgcgggagacagggaatgccagacttctttggagaccagtatc
ttcactcccagtccttgtaaaattccacctccgacgagagtgggctttggaagcgggcag
cctcccccgtatgatcatctttttgaggtggcattgccaaagacagcccatcattttgtc
atcaggaagactgaggagctgttaaagaaagcaaaaggaaacacagaggaagatggtgtg
ccctctacctccccaatggaagtgctggacagactgatacagcagggagcagacgcgcac
agcaaggagctgaacaagttgcctttacccagcaagtctgtcgactggacccactttgga
ggctctcctccttcagatgagatccgcaccctccgagaccagttgcttttactgcacaac
cagttactctatgagcgttttaagaggcagcagcatgccctccggaacaggcggctcctc
cgcaaggtgatcaaagcagcagctctggaggaacataatgctgccatgaaagatcagttg
aagttacaagagaaggacatccagatgtggaaggttagtctgcagaaagaacaagctaga
tacaatcagctccaggagcagcgtgacactatggtaaccaagctccacagccagatcaga
cagctgcagcatgaccgagaggaattctacaaccagagccaggaattacagacgaagctg
gaggactgcaggaacatgattgcggagctgcggatagaactgaagaaggccaacaacaag
gtgtgtcacactgagctgctgctcagtcaggtttcccaaaagctctcaaacagtgagtcg
gtccagcagcagatggagttcttgaacaggcagctgttggttcttggggaggtcaacgag
ctctatttggaacaactgcagaacaagcactcagataccacaaaggaagtagaaatgatg
aaagccgcctatcggaaagagctagaaaaaaacagaagccatgttctccagcagactcag
aggcttgatacctcccaaaaacggattttggaactggaatctcacctggccaagaaagac
caccttcttttggaacagaagaaatatctagaggatgtcaaactccaggcaagaggacag
ctgcaggccgcagagagcaggtatgaggctcagaaaaggataacccaggtgtttgaattg
gagatcttagatttatatggcaggttggagaaagatggcctcctgaaaaaacttgaagaa
gaaaaagcagaagcagctgaagcagcagaagaaaggcttgactgttgtaatgacgggtgc
tcagattccatggtagggcacaatgaagaggcatctggccacaacggtgagaccaagacc
cccaggcccagcagcgcccggggcagtagtggaagcagaggtggtggaggcagcagcagc
agcagcagcgagctttctaccccagagaaacccccacaccagagggcaggcccattcagc
agtcggtgggagacgactatgggagaagcgtctgccagcatccccaccactgtgggctca
cttcccagttcaaaaagcttcctgggtatgaaggctcgagagttatttcgtaataagagc
gagagccagtgtgatgaggacggcatgaccagtagcctttctgagagcctaaagacagaa
ctgggcaaagacttgggtgtggaagccaagattcccctgaacctagatggccctcacccg
tctcccccgaccccggacagtgttggacagctacatatcatggactacaatgagactcat
catgaacacagctaa
DBGET
integrated database retrieval system
