Entry |
|
Name |
Escherichia Tir to TLR2/4-MAPK signaling pathway
|
Definition |
Tir -> SHP1/2 -| (TRAF6+TAK1+TAB2) |
Expanded |
K12784 -> (5777+5781) -| (7189+6885+23118) |
Class |
|
Type |
Pathogen
|
Pathway |
hsa05130 | Pathogenic Escherichia coli infection |
|
Disease |
H00277 | Enterohemorrhagic Escherichia coli (EHEC) infection |
H00278 | Enteropathogenic Escherichia coli (EPEC) infection |
|
Gene |
5777 | PTPN6; protein tyrosine phosphatase non-receptor type 6 |
5781 | PTPN11; protein tyrosine phosphatase non-receptor type 11 |
7189 | TRAF6; TNF receptor associated factor 6 |
6885 | MAP3K7; mitogen-activated protein kinase kinase kinase 7 |
23118 | TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2 |
|
Perturbant |
K12784 (Tir) | tir; translocated intimin receptor |
|
Reference |
|
Authors |
Yan D, Wang X, Luo L, Cao X, Ge B |
Title |
Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs. |
Journal |
|
LinkDB |
|