KEGG   NETWORK: N00926
Entry
N00926                      Network                                
Name
Escherichia Tir to TLR2/4-MAPK signaling pathway
Definition
Tir -> SHP1/2 -| (TRAF6+TAK1+TAB2)
  Expanded
K12784 -> (5777+5781) -| (7189+6885+23118)
Class
nt06517 TLR signaling
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
5777  PTPN6; protein tyrosine phosphatase non-receptor type 6
5781  PTPN11; protein tyrosine phosphatase non-receptor type 11
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Perturbant
K12784 (Tir)  tir; translocated intimin receptor
Reference
  Authors
Yan D, Wang X, Luo L, Cao X, Ge B
  Title
Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs.
  Journal
Nat Immunol 13:1063-71 (2012)
DOI:10.1038/ni.2417
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