Homo sapiens (human): 5777
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Entry
5777 CDS
T01001
Symbol
PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Name
(RefSeq) protein tyrosine phosphatase non-receptor type 6
KO
K05697
tyrosine-protein phosphatase non-receptor type 6 [EC:
3.1.3.48
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04148
Efferocytosis
hsa04520
Adherens junction
hsa04630
JAK-STAT signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa05130
Pathogenic Escherichia coli infection
hsa05140
Leishmaniasis
hsa05205
Proteoglycans in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06180
Pathogenic Escherichia coli
nt06517
TLR signaling
nt06535
Efferocytosis
nt06537
TCR/BCR signaling
Element
N00926
Escherichia Tir to TLR2/4-MAPK signaling pathway
N01165
PDL/PD1-SHP-PI3K signaling pathway
N01785
Don't eat me signal (CD47)
N01786
Don't eat me signal (CD24)
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
5777 (PTPN6)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
5777 (PTPN6)
09144 Cellular community - eukaryotes
04520 Adherens junction
5777 (PTPN6)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
5777 (PTPN6)
04660 T cell receptor signaling pathway
5777 (PTPN6)
04662 B cell receptor signaling pathway
5777 (PTPN6)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
5777 (PTPN6)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5777 (PTPN6)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
5777 (PTPN6)
09174 Infectious disease: parasitic
05140 Leishmaniasis
5777 (PTPN6)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
5777 (PTPN6)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.48 protein-tyrosine-phosphatase
5777 (PTPN6)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein tyrosine phosphatases (PTPs)
Class I PTPs (Classical)
Non-receptor PTPs
5777 (PTPN6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Y_phosphatase
SH2
PTP-SAK
SH2_1
Tc-R-P
DSPc
PTPlike_phytase
Y_phosphatase3
PTP-NADK
Motif
Other DBs
NCBI-GeneID:
5777
NCBI-ProteinID:
NP_002822
OMIM:
176883
HGNC:
9658
Ensembl:
ENSG00000111679
UniProt:
P29350
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:6946577..6961316
Genome browser
AA seq
595 aa
AA seq
DB search
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
NT seq
1788 nt
NT seq
+upstream
nt +downstream
nt
atggtgaggtggtttcaccgagacctcagtgggctggatgcagagaccctgctcaagggc
cgaggtgtccacggtagcttcctggctcggcccagtcgcaagaaccagggtgacttctcg
ctctccgtcagggtgggggatcaggtgacccatattcggatccagaactcaggggatttc
tatgacctgtatggaggggagaagtttgcgactctgacagagctggtggagtactacact
cagcagcagggtgtcctgcaggaccgcgacggcaccatcatccacctcaagtacccgctg
aactgctccgatcccactagtgagaggtggtaccatggccacatgtctggcgggcaggca
gagacgctgctgcaggccaagggcgagccctggacgtttcttgtgcgtgagagcctcagc
cagcctggagacttcgtgctttctgtgctcagtgaccagcccaaggctggcccaggctcc
ccgctcagggtcacccacatcaaggtcatgtgcgagggtggacgctacacagtgggtggt
ttggagaccttcgacagcctcacggacctggtggagcatttcaagaagacggggattgag
gaggcctcaggcgcctttgtctacctgcggcagccgtactatgccacgagggtgaatgcg
gctgacattgagaaccgagtgttggaactgaacaagaagcaggagtccgaggatacagcc
aaggctggcttctgggaggagtttgagagtttgcagaagcaggaggtgaagaacttgcac
cagcgtctggaagggcagcggccagagaacaagggcaagaaccgctacaagaacattctc
ccctttgaccacagccgagtgatcctgcagggacgggacagtaacatccccgggtccgac
tacatcaatgccaactacatcaagaaccagctgctaggccctgatgagaacgctaagacc
tacatcgccagccagggttgtctggaggccacggtcaatgacttctggcagatggcgtgg
caggagaacagccgtgtcatcgtcatgaccacccgagaggtggagaaaggccggaacaaa
tgcgtcccatactggcccgaggtgggcatgcagcgtgcttatgggccctactctgtgacc
aactgcggggagcatgacacaaccgaatacaaactccgtaccttacaggtctccccgctg
gacaatggagacctgattcgggagatctggcattaccagtacctgagctggcccgaccat
ggggtccccagtgagcctgggggtgtcctcagcttcctggaccagatcaaccagcggcag
gaaagtctgcctcacgcagggcccatcatcgtgcactgcagcgccggcatcggccgcaca
ggcaccatcattgtcatcgacatgctcatggagaacatctccaccaagggcctggactgt
gacattgacatccagaagaccatccagatggtgcgggcgcagcgctcgggcatggtgcag
acggaggcgcagtacaagttcatctacgtggccatcgcccagttcattgaaaccactaag
aagaagctggaggtcctgcagtcgcagaagggccaggagtcggagtacgggaacatcacc
tatcccccagccatgaagaatgcccatgccaaggcctcccgcacctcgtccaaacacaag
gaggatgtgtatgagaacctgcacactaagaacaagagggaggagaaagtgaagaagcag
cggtcagcagacaaggagaagagcaagggttccctcaagaggaagtga
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