Homo sapiens (human): 5777
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Entry
5777 CDS
T01001
Symbol
PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Name
(RefSeq) protein tyrosine phosphatase non-receptor type 6
KO
K05697
tyrosine-protein phosphatase non-receptor type 6 [EC:
3.1.3.48
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04148
Efferocytosis
hsa04520
Adherens junction
hsa04630
JAK-STAT signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04660
T cell receptor signaling pathway
hsa04662
B cell receptor signaling pathway
hsa05130
Pathogenic Escherichia coli infection
hsa05140
Leishmaniasis
hsa05205
Proteoglycans in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06180
Pathogenic Escherichia coli
nt06517
TLR signaling
nt06535
Efferocytosis
nt06537
TCR/BCR signaling
Element
N00926
Escherichia Tir to TLR2/4-MAPK signaling pathway
N01165
PDL/PD1-SHP-PI3K signaling pathway
N01785
Don't eat me signal (CD47)
N01786
Don't eat me signal (CD24)
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
5777 (PTPN6)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
5777 (PTPN6)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
5777 (PTPN6)
04660 T cell receptor signaling pathway
5777 (PTPN6)
04662 B cell receptor signaling pathway
5777 (PTPN6)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
5777 (PTPN6)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5777 (PTPN6)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
5777 (PTPN6)
09174 Infectious disease: parasitic
05140 Leishmaniasis
5777 (PTPN6)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
5777 (PTPN6)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.48 protein-tyrosine-phosphatase
5777 (PTPN6)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein tyrosine phosphatases (PTPs)
Class I PTPs (Classical)
Non-receptor PTPs
5777 (PTPN6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Y_phosphatase
SH2
PTP-SAK
SH2_1
Tc-R-P
DSPc
PTPlike_phytase
Y_phosphatase3
PTP-NADK
Motif
Other DBs
NCBI-GeneID:
5777
NCBI-ProteinID:
NP_002822
OMIM:
176883
HGNC:
9658
Ensembl:
ENSG00000111679
UniProt:
P29350
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:6946577..6961316
Genome browser
AA seq
595 aa
AA seq
DB search
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
NT seq
1788 nt
NT seq
+upstream
nt +downstream
nt
atggtgaggtggtttcaccgagacctcagtgggctggatgcagagaccctgctcaagggc
cgaggtgtccacggtagcttcctggctcggcccagtcgcaagaaccagggtgacttctcg
ctctccgtcagggtgggggatcaggtgacccatattcggatccagaactcaggggatttc
tatgacctgtatggaggggagaagtttgcgactctgacagagctggtggagtactacact
cagcagcagggtgtcctgcaggaccgcgacggcaccatcatccacctcaagtacccgctg
aactgctccgatcccactagtgagaggtggtaccatggccacatgtctggcgggcaggca
gagacgctgctgcaggccaagggcgagccctggacgtttcttgtgcgtgagagcctcagc
cagcctggagacttcgtgctttctgtgctcagtgaccagcccaaggctggcccaggctcc
ccgctcagggtcacccacatcaaggtcatgtgcgagggtggacgctacacagtgggtggt
ttggagaccttcgacagcctcacggacctggtggagcatttcaagaagacggggattgag
gaggcctcaggcgcctttgtctacctgcggcagccgtactatgccacgagggtgaatgcg
gctgacattgagaaccgagtgttggaactgaacaagaagcaggagtccgaggatacagcc
aaggctggcttctgggaggagtttgagagtttgcagaagcaggaggtgaagaacttgcac
cagcgtctggaagggcagcggccagagaacaagggcaagaaccgctacaagaacattctc
ccctttgaccacagccgagtgatcctgcagggacgggacagtaacatccccgggtccgac
tacatcaatgccaactacatcaagaaccagctgctaggccctgatgagaacgctaagacc
tacatcgccagccagggttgtctggaggccacggtcaatgacttctggcagatggcgtgg
caggagaacagccgtgtcatcgtcatgaccacccgagaggtggagaaaggccggaacaaa
tgcgtcccatactggcccgaggtgggcatgcagcgtgcttatgggccctactctgtgacc
aactgcggggagcatgacacaaccgaatacaaactccgtaccttacaggtctccccgctg
gacaatggagacctgattcgggagatctggcattaccagtacctgagctggcccgaccat
ggggtccccagtgagcctgggggtgtcctcagcttcctggaccagatcaaccagcggcag
gaaagtctgcctcacgcagggcccatcatcgtgcactgcagcgccggcatcggccgcaca
ggcaccatcattgtcatcgacatgctcatggagaacatctccaccaagggcctggactgt
gacattgacatccagaagaccatccagatggtgcgggcgcagcgctcgggcatggtgcag
acggaggcgcagtacaagttcatctacgtggccatcgcccagttcattgaaaccactaag
aagaagctggaggtcctgcagtcgcagaagggccaggagtcggagtacgggaacatcacc
tatcccccagccatgaagaatgcccatgccaaggcctcccgcacctcgtccaaacacaag
gaggatgtgtatgagaacctgcacactaagaacaagagggaggagaaagtgaagaagcag
cggtcagcagacaaggagaagagcaagggttccctcaagaggaagtga
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