KEGG   NETWORK: N01000
Entry
N01000                      Network                                
Name
mAChR-Ca2+ -apoptotic pathway
Definition
ACh -> mAChR -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS
  Expanded
C01996 -> (1128,1131,1133) -> 2776 -> (23236,5330,5331,5332) -> C01245 -> (3708,3709,3710) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205
Class
nt06528 Calcium signaling
nt06460 Alzheimer disease
nt06466 Pathways of neurodegeneration
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
1128  CHRM1; cholinergic receptor muscarinic 1
1131  CHRM3; cholinergic receptor muscarinic 3
1133  CHRM5; cholinergic receptor muscarinic 5
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
90550  MCU; mitochondrial calcium uniporter
7416  VDAC1; voltage dependent anion channel 1
7417  VDAC2; voltage dependent anion channel 2
7419  VDAC3; voltage dependent anion channel 3
291  SLC25A4; solute carrier family 25 member 4
292  SLC25A5; solute carrier family 25 member 5
293  SLC25A6; solute carrier family 25 member 6
83447  SLC25A31; solute carrier family 25 member 31
54205  CYCS; cytochrome c, somatic
Metabolite
C01996  Acetylcholine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
C00076  Calcium cation
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:28867646
  Authors
Penna E, Espino J, De Stefani D, Rizzuto R
  Title
The MCU complex in cell death.
  Journal
Cell Calcium 69:73-80 (2018)
DOI:10.1016/j.ceca.2017.08.008
Reference
PMID:29409699
  Authors
Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P
  Title
Calcium Dynamics as a Machine for Decoding Signals.
  Journal
Trends Cell Biol 28:258-273 (2018)
DOI:10.1016/j.tcb.2018.01.002
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