Homo sapiens (human): 90550
Help
Entry
90550 CDS
T01001
Symbol
MCU, C10orf42, CCDC109A, HsMCU
Name
(RefSeq) mitochondrial calcium uniporter
KO
K20858
calcium uniporter protein, mitochondrial
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04218
Cellular senescence
hsa04621
NOD-like receptor signaling pathway
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05017
Spinocerebellar ataxia
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06528
Calcium signaling
Element
N00957
Mutation-caused abberant ATXN2/3 to mGluR5-Ca2+ -apoptotic pathway
N00967
VGCC-Ca2+ -apoptotic pathway
N00984
mGluR5-Ca2+ -apoptotic pathway
N00985
Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway
N00987
Mutation-caused aberrant Htt to transport of calcium
N01000
mAChR-Ca2+ -apoptotic pathway
N01001
Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway
N01002
Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway
N01003
Mutation-caused aberrant Abeta to transport of calcium
N01004
Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway
N01007
Mutation-caused aberrant PSEN to mGluR5-Ca2+ -apoptotic pathway
N01008
Mutation-caused aberrant PSEN1 to mGluR5-Ca2+ -apoptotic pathway
N01031
Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway
N01151
Mutation-inactivated SIGMAR1 to Ca2+ -apoptotic pathway
N01199
Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway
N01200
Scrapie conformation PrPSc to transport of calcium
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
90550 (MCU)
05012 Parkinson disease
90550 (MCU)
05014 Amyotrophic lateral sclerosis
90550 (MCU)
05017 Spinocerebellar ataxia
90550 (MCU)
05020 Prion disease
90550 (MCU)
05022 Pathways of neurodegeneration - multiple diseases
90550 (MCU)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03029 Mitochondrial biogenesis [BR:
hsa03029
]
90550 (MCU)
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
90550 (MCU)
Mitochondrial biogenesis [BR:
hsa03029
]
Mitochondrial protein import machinery
Inner mambrane
Mitochondrial calcium uniporter complex
90550 (MCU)
Transporters [BR:
hsa02000
]
Other transporters
Pores ion channels [TC:
1
]
90550 (MCU)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MCU
Spectrin_Anc-1
SPX
Motif
Other DBs
NCBI-GeneID:
90550
NCBI-ProteinID:
NP_612366
OMIM:
614197
HGNC:
23526
Ensembl:
ENSG00000156026
UniProt:
Q8NE86
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:72692143..72887694
Genome browser
AA seq
351 aa
AA seq
DB search
MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQN
LGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDR
GIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVK
TLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGL
AYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYL
LFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD
NT seq
1056 nt
NT seq
+upstream
nt +downstream
nt
atggcggccgccgcaggtagatcgctcctgctgctcctctcctctcggggcggcggcggc
gggggcgccggcggctgcggggcgctgactgccggctgcttccctgggctgggcgtcagc
cgccaccggcagcagcagcaccaccggacggtacaccagaggatcgcttcctggcagaat
ttgggagctgtttattgcagcactgttgtgccctctgatgatgttacagtggtttatcaa
aatgggttacctgtgatatctgtgaggctaccatcccggcgtgaacgctgtcagttcaca
ctcaagcctatctctgactctgttggtgtatttttacgacaactgcaagaagaggatcgg
ggaattgacagagttgctatctattcaccagatggtgttcgcgttgctgcttcaacagga
atagacctcctcctccttgatgactttaagctggtcattaatgacttaacataccacgta
cgaccaccaaaaagagacctcttaagtcatgaaaatgcagcaacgctgaatgatgtaaag
acattggtccagcaactatacaccacactgtgcattgagcagcaccagttaaacaaggaa
agggagcttattgaaagactagaggatctcaaagagcagctggctcccctggaaaaggta
cgaattgagattagcagaaaagctgagaagaggaccactttggtgctatggggtggcctt
gcctacatggccacacagtttggcattttggcccggcttacctggtgggaatattcctgg
gacatcatggagccagtaacatacttcatcacttatggaagtgccatggcaatgtatgca
tattttgtaatgacacgccaggaatatgtttatccagaagccagagacagacaatactta
ctatttttccataaaggagccaaaaagtcacgttttgacctagagaaatacaatcaactc
aaggatgcaattgctcaggcagaaatggaccttaagagactgagagacccattacaagta
catctgcctctccgacaaattggtgaaaaagattga
DBGET
integrated database retrieval system
