| Entry |
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| Name |
Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
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| Definition |
APP* -> Abeta -> FAS -> FADD -> CASP8 -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3 |
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| Expanded |
351v1 -> (C16515,C16514) -> 355 -> 8772 -> 841 -> 637 -> (581,578) -> 54205 == 317 -> 842 -> 836 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 351 | APP; amyloid beta precursor protein |
| 355 | FAS; Fas cell surface death receptor |
| 8772 | FADD; Fas associated via death domain |
| 637 | BID; BH3 interacting domain death agonist |
| 581 | BAX; BCL2 associated X, apoptosis regulator |
| 578 | BAK1; BCL2 antagonist/killer 1 |
| 54205 | CYCS; cytochrome c, somatic |
| 317 | APAF1; apoptotic peptidase activating factor 1 |
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| Variant |
351v1 (APP*) APP mutation
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| Metabolite |
| C16515 | Beta-amyloid protein 42 |
| C16514 | Beta-amyloid protein 40 |
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| Reference |
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| Authors |
Small DH, Mok SS, Bornstein JC |
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| Title |
Alzheimer's disease and Abeta toxicity: from top to bottom. |
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| Journal |
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| Reference |
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| Authors |
Shen Y, He P, Zhong Z, McAllister C, Lindholm K |
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| Title |
Distinct destructive signal pathways of neuronal death in Alzheimer's disease. |
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| Journal |
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| Reference |
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| Authors |
Ivins KJ, Thornton PL, Rohn TT, Cotman CW |
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| Title |
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. |
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| Journal |
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| LinkDB |
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