KEGG   NETWORK: N01014
Entry
N01014                      Network                                
Name
Mutation-caused aberrant Abeta to IRE1a-JNK signaling pathway
Definition
APP* -> Abeta -> MAP3K5 -> MAP2K7 -> JNK
  Expanded
351v1 -> (C16515,C16514) -> 4217 -> 5609 -> (5599,5601,5602)
Class
nt06534 Unfolded protein response
nt06460 Alzheimer disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
4217  MAP3K5; mitogen-activated protein kinase kinase kinase 5
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
Reference
PMID:24715417
  Authors
Li JQ, Yu JT, Jiang T, Tan L
  Title
Endoplasmic reticulum dysfunction in Alzheimer's disease.
  Journal
Mol Neurobiol 51:383-95 (2015)
DOI:10.1007/s12035-014-8695-8
Reference
PMID:24481061
  Authors
Song J, Park KA, Lee WT, Lee JE
  Title
Apoptosis signal regulating kinase 1 (ASK1): potential as a therapeutic target for Alzheimer's disease.
  Journal
Int J Mol Sci 15:2119-29 (2014)
DOI:10.3390/ijms15022119
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