Homo sapiens (human): 5609
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Entry
5609 CDS
T01001
Symbol
MAP2K7, JNKK2, MAPKK7, MEK, MEK_7, MKK7, PRKMK7, SAPKK-4, SAPKK4
Name
(RefSeq) mitogen-activated protein kinase kinase 7
KO
K04431
mitogen-activated protein kinase kinase 7 [EC:
2.7.12.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04012
ErbB signaling pathway
hsa04141
Protein processing in endoplasmic reticulum
hsa04380
Osteoclast differentiation
hsa04530
Tight junction
hsa04620
Toll-like receptor signaling pathway
hsa04660
T cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04668
TNF signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04912
GnRH signaling pathway
hsa04926
Relaxin signaling pathway
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05016
Huntington disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05132
Salmonella infection
hsa05135
Yersinia infection
hsa05161
Hepatitis B
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06211
Other MAPK signaling (cancer)
nt06223
TNF signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06466
Pathways of neurodegeneration
nt06516
TNF signaling
nt06517
TLR signaling
nt06526
MAPK signaling
nt06534
Unfolded protein response
Element
N00188
IL1-IL1R-JNK signaling pathway
N00189
KSHV K15 to JNK signaling pathway
N00438
TLR2/4-MAPK signaling pathway
N00446
TNF-JNK signaling pathway
N00862
Yersinia YopP/J to TLR2/4-MAPK signaling pathway
N00992
Mutation-caused aberrant Htt to TNF-JNK signaling pathway
N01013
IRE1a-JNK signaling pathway
N01014
Mutation-caused aberrant Abeta to IRE1a-JNK signaling pathway
N01125
Salmonella AvrA to TNF-JNK signaling pathway
N01407
Metals to JNK signaling pathway
N01594
MLK-JNK signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
5609 (MAP2K7)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5609 (MAP2K7)
04012 ErbB signaling pathway
5609 (MAP2K7)
04668 TNF signaling pathway
5609 (MAP2K7)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04530 Tight junction
5609 (MAP2K7)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
5609 (MAP2K7)
04660 T cell receptor signaling pathway
5609 (MAP2K7)
04664 Fc epsilon RI signaling pathway
5609 (MAP2K7)
09152 Endocrine system
04912 GnRH signaling pathway
5609 (MAP2K7)
04926 Relaxin signaling pathway
5609 (MAP2K7)
09156 Nervous system
04722 Neurotrophin signaling pathway
5609 (MAP2K7)
09158 Development and regeneration
04380 Osteoclast differentiation
5609 (MAP2K7)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
5609 (MAP2K7)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
5609 (MAP2K7)
05161 Hepatitis B
5609 (MAP2K7)
05167 Kaposi sarcoma-associated herpesvirus infection
5609 (MAP2K7)
05169 Epstein-Barr virus infection
5609 (MAP2K7)
09171 Infectious disease: bacterial
05132 Salmonella infection
5609 (MAP2K7)
05135 Yersinia infection
5609 (MAP2K7)
09164 Neurodegenerative disease
05010 Alzheimer disease
5609 (MAP2K7)
05016 Huntington disease
5609 (MAP2K7)
05022 Pathways of neurodegeneration - multiple diseases
5609 (MAP2K7)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5609 (MAP2K7)
05418 Fluid shear stress and atherosclerosis
5609 (MAP2K7)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
5609 (MAP2K7)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
5609 (MAP2K7)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
5609 (MAP2K7)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: STE group
STE7 family
5609 (MAP2K7)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kinase-like
ABC1
Pkinase_fungal
Seadorna_VP7
Haspin_kinase
APH
RIO1
Motif
Other DBs
NCBI-GeneID:
5609
NCBI-ProteinID:
NP_660186
OMIM:
603014
HGNC:
6847
Ensembl:
ENSG00000076984
Pharos:
O14733
(Tbio)
UniProt:
O14733
Structure
PDB
LinkDB
All DBs
Position
19:7903877..7914478
Genome browser
AA seq
419 aa
AA seq
DB search
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
NT seq
1260 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgtcctccctggaacagaagctgtcccgcctggaagcaaagctgaagcaggag
aaccgggaggcccggcggaggatcgacctcaacctggatatcagcccccagcggcccagg
cccaccctgcagctcccgctggccaacgatgggggcagccgctcgccatcctcagagagc
tccccgcagcaccccacgccccccgcccggccccgccacatgctggggctcccgtcaacc
ctgttcacaccccgcagcatggagagcattgagattgaccagaagctgcaggagatcatg
aagcagacgggctacctgaccatcgggggccagcgctaccaggcagaaatcaacgacctg
gagaacttgggcgagatgggcagcggcacctgcggccaggtgtggaagatgcgcttccgg
aagaccggccacgtcattgccgttaagcaaatgcggcgctccgggaacaaggaggagaac
aagcgcatcctcatggacctggatgtggtgctgaagagccacgactgcccctacatcgtg
cagtgctttgggacgttcatcaccaacacggacgtcttcatcgccatggagctcatgggc
acctgcgctgagaagctcaagaagcggatgcagggccccatccccgagcgcattctgggc
aagatgacagtggcgattgtgaaggcgctgtactacctgaaggagaagcacggtgtcatc
caccgcgacgtcaagccctccaacatcctgctggacgagcggggccagatcaagctctgc
gacttcggcatcagcggccgcctggtggactccaaagccaagacgcggagcgccggctgt
gccgcctacatggcacccgagcgcattgaccccccagaccccaccaagccggactatgac
atccgggccgacgtatggagcctgggcatctcgttggtggagctggcaacaggacagttt
ccctacaagaactgcaagacggactttgaggtcctcaccaaagtcctacaggaagagccc
ccgcttctgcccggacacatgggcttctcgggggacttccagtccttcgtcaaagactgc
cttactaaagatcacaggaagagaccaaagtataataagctacttgaacacagcttcatc
aagcgctacgagacgctggaggtggacgtggcgtcctggttcaaggatgtcatggcgaag
actgagtcaccgcggactagcggcgtcctgagccagccccacctgcccttcttcaggtag
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