Entry
Name
Escherichia EspJ/Tir to Actin signaling pathway
Definition
EspJ -| (FYN,ABL) -> Tir -> NCK
Expanded
K23648 -| (2534,25) -> K12784 -> (4690,8440)
Class
nt06180 Pathogenic Escherichia coli
Type
Pathogen
Pathway
hsa05130 Pathogenic Escherichia coli infection
Disease
H00277 Enterohemorrhagic Escherichia coli (EHEC) infection
H00278 Enteropathogenic Escherichia coli (EPEC) infection
Gene
2534 FYN; FYN proto-oncogene, Src family tyrosine kinase
25 ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
4690 NCK1; NCK adaptor protein 1
8440 NCK2; NCK adaptor protein 2
Perturbant
K23648 (EspJ) espJ; T3SS secreted effector ADP-ribosyltransferase EspJ
K12784 (Tir) tir; translocated intimin receptor
Reference
Authors
Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel G
Title
The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation.
Journal
Reference
Authors
Lai Y, Rosenshine I, Leong JM, Frankel G
Title
Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.
Journal
LinkDB
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