Homo sapiens (human): 2534
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Entry
2534 CDS
T01001
Symbol
FYN, SLK, SYN, p59-FYN
Name
(RefSeq) FYN proto-oncogene, Src family tyrosine kinase
KO
K05703
tyrosine-protein kinase Fyn [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04071
Sphingolipid signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04360
Axon guidance
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04611
Platelet activation
hsa04650
Natural killer cell mediated cytotoxicity
hsa04660
T cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04725
Cholinergic synapse
hsa05020
Prion disease
hsa05130
Pathogenic Escherichia coli infection
hsa05416
Viral myocarditis
Network
nt06180
Pathogenic Escherichia coli
nt06183
Yersinia
nt06465
Prion disease
nt06537
TCR/BCR signaling
nt06541
Cytoskeleton in neurons
Element
N01093
Escherichia EspJ/Tir to Actin signaling pathway
N01106
TCR-PLCG-ITPR signaling pathway
N01204
PRNP-PI3K-NOX2 signaling pathway
N01205
Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
N01835
SEMA3-CRMP2/MAPT axon guidance signaling
Drug target
Dasatinib (
DG00714
):
D03658
<JP>
D06414
<JP/US>
D12609
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04072 Phospholipase D signaling pathway
2534 (FYN)
04071 Sphingolipid signaling pathway
2534 (FYN)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
2534 (FYN)
04650 Natural killer cell mediated cytotoxicity
2534 (FYN)
04660 T cell receptor signaling pathway
2534 (FYN)
04664 Fc epsilon RI signaling pathway
2534 (FYN)
09156 Nervous system
04725 Cholinergic synapse
2534 (FYN)
09158 Development and regeneration
04360 Axon guidance
2534 (FYN)
04380 Osteoclast differentiation
2534 (FYN)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
2534 (FYN)
09164 Neurodegenerative disease
05020 Prion disease
2534 (FYN)
09166 Cardiovascular disease
05416 Viral myocarditis
2534 (FYN)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
2534 (FYN)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
2534 (FYN)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
2534 (FYN)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SRC family
2534 (FYN)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
2534 (FYN)
Endocytosis
Lipid raft mediated endocytosis
Flotillin-dependent endocytosis
2534 (FYN)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_9
SH3_2
SH3_10
SH3_3
Haspin_kinase
ABC1
SH2_1
zf-RING_14
DUF7063
Motif
Other DBs
NCBI-GeneID:
2534
NCBI-ProteinID:
NP_002028
OMIM:
137025
HGNC:
4037
Ensembl:
ENSG00000010810
UniProt:
P06241
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:complement(111660332..111873452)
Genome browser
AA seq
537 aa
AA seq
DB search
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
NT seq
1614 nt
NT seq
+upstream
nt +downstream
nt
atgggctgtgtgcaatgtaaggataaagaagcaacaaaactgacggaggagagggacggc
agcctgaaccagagctctgggtaccgctatggcacagaccccacccctcagcactacccc
agcttcggtgtgacctccatccccaactacaacaacttccacgcagccgggggccaagga
ctcaccgtctttggaggtgtgaactcttcgtctcatacggggaccttgcgtacgagagga
ggaacaggagtgacactctttgtggccctttatgactatgaagcacggacagaagatgac
ctgagttttcacaaaggagaaaaatttcaaatattgaacagctcggaaggagattggtgg
gaagcccgctccttgacaactggagagacaggttacattcccagcaattatgtggctcca
gttgactctatccaggcagaagagtggtactttggaaaacttggccgaaaagatgctgag
cgacagctattgtcctttggaaacccaagaggtacctttcttatccgcgagagtgaaacc
accaaaggtgcctattcactttctatccgtgattgggatgatatgaaaggagaccatgtc
aaacattataaaattcgcaaacttgacaatggtggatactacattaccacccgggcccag
tttgaaacacttcagcagcttgtacaacattactcagagagagctgcaggtctctgctgc
cgcctagtagttccctgtcacaaagggatgccaaggcttaccgatctgtctgtcaaaacc
aaagatgtctgggaaatccctcgagaatccctgcagttgatcaagagactgggaaatggg
cagtttggggaagtatggatgggtacctggaatggaaacacaaaagtagccataaagact
cttaaaccaggcacaatgtcccccgaatcattccttgaggaagcgcagatcatgaagaag
ctgaagcacgacaagctggtccagctctatgcagtggtgtctgaggagcccatctacatc
gtcaccgagtatatgaacaaaggaagtttactggatttcttaaaagatggagaaggaaga
gctctgaaattaccaaatcttgtggacatggcagcacaggtggctgcaggaatggcttac
atcgagcgcatgaattatatccatagagatctgcgatcagcaaacattctagtggggaat
ggactcatatgcaagattgctgacttcggattggcccgattgatagaagacaatgagtac
acagcaagacaaggtgcaaagttccccatcaagtggacggcccccgaggcagccctgtac
gggaggttcacaatcaagtctgacgtgtggtcttttggaatcttactcacagagctggtc
accaaaggaagagtgccatacccaggcatgaacaaccgggaggtgctggagcaggtggag
cgaggctacaggatgccctgcccgcaggactgccccatctctctgcatgagctcatgatc
cactgctggaaaaaggaccctgaagaacgccccacttttgagtacttgcagagcttcctg
gaagactactttaccgcgacagagccccagtaccaacctggtgaaaacctgtaa
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