KEGG   NETWORK: N01104
Entry
N01104                      Network                                

Name
LPA-GNAQ/11-RhoA signaling pathway
Definition
LPA -> LPAR -> (GNAQ,GNA11) -> ARHGEF12 -> RHOA
  Expanded
C00681 -> (1902,9170,23566,2846,57121) -> (2776,2767) -> 23365 -> 387
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Reference
Gene
1902  LPAR1; lysophosphatidic acid receptor 1
9170  LPAR2; lysophosphatidic acid receptor 2
23566  LPAR3; lysophosphatidic acid receptor 3
2846  LPAR4; lysophosphatidic acid receptor 4
57121  LPAR5; lysophosphatidic acid receptor 5
2776  GNAQ; G protein subunit alpha q
2767  GNA11; G protein subunit alpha 11
23365  ARHGEF12; Rho guanine nucleotide exchange factor 12
387  RHOA; ras homolog family member A
Metabolite
C00681  1-Acyl-sn-glycerol 3-phosphate
Reference
  Authors
Vogt S, Grosse R, Schultz G, Offermanns S
  Title
Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.
  Journal
J Biol Chem 278:28743-9 (2003)
DOI:10.1074/jbc.M304570200
Reference
  Authors
Aittaleb M, Boguth CA, Tesmer JJ
  Title
Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.
  Journal
Mol Pharmacol 77:111-25 (2010)
DOI:10.1124/mol.109.061234
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