KEGG   NETWORK: N01106
Entry
N01106                      Network                                
Name
TCR-PLCG-ITPR signaling pathway
Definition
(TCR+CD3+CD4) -> (LCK,FYN,ZAP70) -> (SLP76+GADS+LAT+VAV) -> PLCG -> IP3 -> ITPR -> Ca2+(cyto)
  Expanded
((915+916+917+919)+920) -> (3932,2534,7535) -> (3937+9402+27040+(7409,7410,10451)) -> (5335,5336) -> C01245 -> (3708,3709,3710) -> C00076
Class
nt06537 TCR/BCR signaling
nt06183 Yersinia
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
hsa04660  T cell receptor signaling pathway
Gene
915  CD3D; CD3 delta subunit of T-cell receptor complex
916  CD3E; CD3 epsilon subunit of T-cell receptor complex
917  CD3G; CD3 gamma subunit of T-cell receptor complex
919  CD247; CD247 molecule
920  CD4; CD4 molecule
3932  LCK; LCK proto-oncogene, Src family tyrosine kinase
2534  FYN; FYN proto-oncogene, Src family tyrosine kinase
7535  ZAP70; zeta chain of T cell receptor associated protein kinase 70
3937  LCP2; lymphocyte cytosolic protein 2
9402  GRAP2; GRB2 related adaptor protein 2
27040  LAT; linker for activation of T cells
7409  VAV1; vav guanine nucleotide exchange factor 1
7410  VAV2; vav guanine nucleotide exchange factor 2
10451  VAV3; vav guanine nucleotide exchange factor 3
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
PMID:29789755
  Authors
Gaud G, Lesourne R, Love PE
  Title
Regulatory mechanisms in T cell receptor signalling.
  Journal
Nat Rev Immunol 18:485-497 (2018)
DOI:10.1038/s41577-018-0020-8
Reference
PMID:23524462
  Authors
Brownlie RJ, Zamoyska R
  Title
T cell receptor signalling networks: branched, diversified and bounded.
  Journal
Nat Rev Immunol 13:257-69 (2013)
DOI:10.1038/nri3403
Reference
PMID:30622345
  Authors
Trebak M, Kinet JP
  Title
Calcium signalling in T cells.
  Journal
Nat Rev Immunol 19:154-169 (2019)
DOI:10.1038/s41577-018-0110-7
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