KEGG   NETWORK: N01106
Entry
N01106                      Network                                
Name
TCR-NFAT signaling pathway
Definition
(CD4,CD8) -> LCK -> (TCR+ZAP70) -> (SLP76,GADS,LAT,VAV) -> PLCG -> IP3 -> Ca2+ -> CALM == CN -> NFAT
  Expanded
(920,(925,926)) -> 3932 -> 7535 -> (3937,9402,27040,(7409,7410,10451)) -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) == (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class
nt06120 Calcium signaling (viruses and bacteria)
Type
Reference
Pathway
hsa04660  T cell receptor signaling pathway
Gene
920  CD4; CD4 molecule
925  CD8A; CD8a molecule
926  CD8B; CD8b molecule
3932  LCK; LCK proto-oncogene, Src family tyrosine kinase
7535  ZAP70; zeta chain of T cell receptor associated protein kinase 70
3937  LCP2; lymphocyte cytosolic protein 2
9402  GRAP2; GRB2 related adaptor protein 2
27040  LAT; linker for activation of T cells
7409  VAV1; vav guanine nucleotide exchange factor 1
7410  VAV2; vav guanine nucleotide exchange factor 2
10451  VAV3; vav guanine nucleotide exchange factor 3
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T cells 1
4773  NFATC2; nuclear factor of activated T cells 2
4775  NFATC3; nuclear factor of activated T cells 3
4776  NFATC4; nuclear factor of activated T cells 4
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
PMID:29789755
  Authors
Gaud G, Lesourne R, Love PE
  Title
Regulatory mechanisms in T cell receptor signalling.
  Journal
Nat Rev Immunol 18:485-497 (2018)
DOI:10.1038/s41577-018-0020-8
Reference
PMID:23524462
  Authors
Brownlie RJ, Zamoyska R
  Title
T cell receptor signalling networks: branched, diversified and bounded.
  Journal
Nat Rev Immunol 13:257-69 (2013)
DOI:10.1038/nri3403
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