 | | NETWORK: N01106 | |
Entry |
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Name |
TCR-NFAT signaling pathway
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Definition |
(CD4,CD8) -> LCK -> (TCR+ZAP70) -> (SLP76,GADS,LAT,VAV) -> PLCG -> IP3 -> Ca2+ -> CALM == CN -> NFAT |
Expanded |
(920,(925,926)) -> 3932 -> 7535 -> (3937,9402,27040,(7409,7410,10451)) -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) == (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776) |
Class |
nt06120 Calcium signaling (viruses and bacteria)
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Type |
Reference
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Pathway |
hsa04660 | T cell receptor signaling pathway |
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Gene |
3932 | LCK; LCK proto-oncogene, Src family tyrosine kinase |
7535 | ZAP70; zeta chain of T cell receptor associated protein kinase 70 |
3937 | LCP2; lymphocyte cytosolic protein 2 |
9402 | GRAP2; GRB2 related adaptor protein 2 |
27040 | LAT; linker for activation of T cells |
7409 | VAV1; vav guanine nucleotide exchange factor 1 |
7410 | VAV2; vav guanine nucleotide exchange factor 2 |
10451 | VAV3; vav guanine nucleotide exchange factor 3 |
5335 | PLCG1; phospholipase C gamma 1 |
5336 | PLCG2; phospholipase C gamma 2 |
5530 | PPP3CA; protein phosphatase 3 catalytic subunit alpha |
5532 | PPP3CB; protein phosphatase 3 catalytic subunit beta |
5533 | PPP3CC; protein phosphatase 3 catalytic subunit gamma |
5534 | PPP3R1; protein phosphatase 3 regulatory subunit B, alpha |
5535 | PPP3R2; protein phosphatase 3 regulatory subunit B, beta |
4772 | NFATC1; nuclear factor of activated T cells 1 |
4773 | NFATC2; nuclear factor of activated T cells 2 |
4775 | NFATC3; nuclear factor of activated T cells 3 |
4776 | NFATC4; nuclear factor of activated T cells 4 |
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Metabolite |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
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Reference |
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Authors |
Gaud G, Lesourne R, Love PE |
Title |
Regulatory mechanisms in T cell receptor signalling. |
Journal |
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Reference |
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Authors |
Brownlie RJ, Zamoyska R |
Title |
T cell receptor signalling networks: branched, diversified and bounded. |
Journal |
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LinkDB |
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