KEGG   Homo sapiens (human): 917
Entry
917               CDS       T01001                                 
Symbol
CD3G, CD3-GAMMA, CD3GAMMA, IMD17, T3G
Name
(RefSeq) CD3 gamma subunit of T-cell receptor complex
  KO
K06452  T-cell surface glycoprotein CD3 gamma chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05142  Chagas disease
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00093  Combined immunodeficiency
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Blinatumomab: D09325<JP/US>
Catumaxomab: D09207
Flotetuzumab: D11306
Muromonab-CD3: D05092
Otelixizumab: D08959
Tebentafusp: D12296<US>
Teplizumab: D09013
Visilizumab: D06314
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    917 (CD3G)
   04660 T cell receptor signaling pathway
    917 (CD3G)
   04658 Th1 and Th2 cell differentiation
    917 (CD3G)
   04659 Th17 cell differentiation
    917 (CD3G)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    917 (CD3G)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    917 (CD3G)
   05170 Human immunodeficiency virus 1 infection
    917 (CD3G)
   05162 Measles
    917 (CD3G)
   05169 Epstein-Barr virus infection
    917 (CD3G)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    917 (CD3G)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    917 (CD3G)
CD molecules [BR:hsa04090]
 Proteins
  917 (CD3G)
SSDB
Motif
Pfam: Ig_4 Ig_5 ITAM Ig_3 Ig_2
Other DBs
NCBI-GeneID: 917
NCBI-ProteinID: NP_000064
OMIM: 186740
HGNC: 1675
Ensembl: ENSG00000160654
Pharos: P09693(Tclin)
UniProt: P09693 B0YIY5
Structure
LinkDB
Position
11:118344344..118355161
AA seq 182 aa
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGK
MIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLF
AEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLR
RN
NT seq 549 nt   +upstreamnt  +downstreamnt
atggaacaggggaagggcctggctgtcctcatcctggctatcattcttcttcaaggtact
ttggcccagtcaatcaaaggaaaccacttggttaaggtgtatgactatcaagaagatggt
tcggtacttctgacttgtgatgcagaagccaaaaatatcacatggtttaaagatgggaag
atgatcggcttcctaactgaagataaaaaaaaatggaatctgggaagtaatgccaaggac
cctcgagggatgtatcagtgtaaaggatcacagaacaagtcaaaaccactccaagtgtat
tacagaatgtgtcagaactgcattgaactaaatgcagccaccatatctggctttctcttt
gctgaaatcgtcagcattttcgtccttgctgttggggtctacttcattgctggacaggat
ggagttcgccagtcgagagcttcagacaagcagactctgttgcccaatgaccagctctac
cagcccctcaaggatcgagaagatgaccagtacagccaccttcaaggaaaccagttgagg
aggaattga

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