KEGG   NETWORK: N01345
Entry
N01345                      Network                                

Name
EP/NE-ADRB-cAMP signaling pathway
Definition
(EP,NE) -> ADRB2 -> GNAS -> ADCY -> cAMP -> PKA -> PLN
  Expanded
(C00788,C00547) -> 154 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) -> 5350
Class
nt06234 cAMP signaling
Type
Reference
Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
Gene
154  ADRB2; adrenoceptor beta 2
2778  GNAS; GNAS complex locus
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
5350  PLN; phospholamban
Metabolite
C00788  L-Adrenaline
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
Reference
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
  Authors
Lohse MJ, Engelhardt S, Eschenhagen T
  Title
What is the role of beta-adrenergic signaling in heart failure?
  Journal
Circ Res 93:896-906 (2003)
DOI:10.1161/01.RES.0000102042.83024.CA
Reference
  Authors
Spadari RC, Cavadas C, de Carvalho AETS, Ortolani D, de Moura AL, Vassalo PF
  Title
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.
  Journal
Cell Mol Neurobiol 38:109-120 (2018)
DOI:10.1007/s10571-017-0557-2
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