| Entry |
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| Name |
EP/NE-ADRB-PI3K signaling pathway
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| Definition |
(EP,NE) -> ADRB2 -> GNAI -> PI3K -> PIP3 -> AKT |
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| Expanded |
(C00788,C00547) -> 154 -> (2770,2771,2773) -> (5290,5291,5293) -> C05981 -> (207,208,10000) |
|---|
| Class |
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| Type |
Reference
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Gene |
| 154 | ADRB2; adrenoceptor beta 2 |
| 2770 | GNAI1; G protein subunit alpha i1 |
| 2771 | GNAI2; G protein subunit alpha i2 |
| 2773 | GNAI3; G protein subunit alpha i3 |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
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| Authors |
Lohse MJ, Engelhardt S, Eschenhagen T |
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| Title |
What is the role of beta-adrenergic signaling in heart failure? |
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| Journal |
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| Reference |
|
|---|
| Authors |
Spadari RC, Cavadas C, de Carvalho AETS, Ortolani D, de Moura AL, Vassalo PF |
|---|
| Title |
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. |
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| Journal |
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| LinkDB |
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