KEGG   NETWORK: N01347
Entry
N01347                      Network                                

Name
EP/NE-ADRB-PI3K signaling pathway
Definition
(EP,NE) -> ADRB2 -> GNAI -> PI3K -> PIP3 -> AKT
  Expanded
(C00788,C00547) -> 154 -> (2770,2771,2773) -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling
Type
Reference
Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
Gene
154  ADRB2; adrenoceptor beta 2
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Metabolite
C00788  L-Adrenaline
C00547  L-Noradrenaline
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Lohse MJ, Engelhardt S, Eschenhagen T
  Title
What is the role of beta-adrenergic signaling in heart failure?
  Journal
Circ Res 93:896-906 (2003)
DOI:10.1161/01.RES.0000102042.83024.CA
Reference
  Authors
Spadari RC, Cavadas C, de Carvalho AETS, Ortolani D, de Moura AL, Vassalo PF
  Title
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.
  Journal
Cell Mol Neurobiol 38:109-120 (2018)
DOI:10.1007/s10571-017-0557-2
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