KEGG   NETWORK: N01348
Entry
N01348                      Network                                
Name
Nicotine/NNK to PI3K signaling pathway
Definition
(Nicotine,NNK) -> ADRB2 -> GNAI -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
(C00745,C16453) -> 154 -> (2770,2771,2773) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06214 PI3K signaling (cancer)
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
Gene
154  ADRB2; adrenoceptor beta 2
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Perturbant
C00745 (Nicotine)  Nicotine
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
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