| Entry |
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| Name |
Arsenic to PI3K signaling pathway
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| Definition |
Arsenic -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K |
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| Expanded |
(C06697,C11906) -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199) |
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| Class |
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| Type |
Env factor
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| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 1956 | EGFR; epidermal growth factor receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 2475 | MTOR; mechanistic target of rapamycin kinase |
| 6198 | RPS6KB1; ribosomal protein S6 kinase B1 |
| 6199 | RPS6KB2; ribosomal protein S6 kinase B2 |
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| Perturbant |
| C11906 (Arsenic) | Sodium arsenite |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Chen QY, Costa M |
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| Title |
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis. |
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| Journal |
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| Reference |
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| Authors |
Beezhold K, Liu J, Kan H, Meighan T, Castranova V, Shi X, Chen F |
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| Title |
miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. |
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| Journal |
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| Reference |
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| Authors |
Carpenter RL, Jiang Y, Jing Y, He J, Rojanasakul Y, Liu LZ, Jiang BH |
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| Title |
Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1. |
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| Journal |
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| LinkDB |
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