KEGG   NETWORK: N01355
Entry
N01355                      Network                                

Name
Arsenic to PI3K signaling pathway
Definition
Arsenic -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
(C06697,C11906) -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06214 PI3K signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
Gene
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin kinase
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Perturbant
C06697 (Arsenic)  Arsenite
C11906 (Arsenic)  Sodium arsenite
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Chen QY, Costa M
  Title
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis.
  Journal
Mol Pharmacol 94:784-792 (2018)
DOI:10.1124/mol.118.112268
Reference
  Authors
Beezhold K, Liu J, Kan H, Meighan T, Castranova V, Shi X, Chen F
  Title
miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis.
  Journal
Toxicol Sci 123:411-20 (2011)
DOI:10.1093/toxsci/kfr188
Reference
  Authors
Carpenter RL, Jiang Y, Jing Y, He J, Rojanasakul Y, Liu LZ, Jiang BH
  Title
Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1.
  Journal
Biochem Biophys Res Commun 414:533-8 (2011)
DOI:10.1016/j.bbrc.2011.09.102
LinkDB

DBGET integrated database retrieval system