KEGG   NETWORK: N01357
Entry
N01357                      Network                                
Name
P4/MPA to membrane-initiated progesterone signaling pathway
Definition
(P4,MPA) -> mPR -> PI3K -> PIP3 -> AKT
  Expanded
(C00410,C08150) -> (164091,85315,54852) -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling (cancer)
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00031  Breast cancer
Gene
164091  PAQR7; progestin and adipoQ receptor family member 7
85315  PAQR8; progestin and adipoQ receptor family member 8
54852  PAQR5; progestin and adipoQ receptor family member 5
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
C00410 (P4)  Progesterone
C08150 (MPA)  Medroxyprogesterone acetate
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27368976
  Authors
Valadez-Cosmes P, Vazquez-Martinez ER, Cerbon M, Camacho-Arroyo I
  Title
Membrane progesterone receptors in reproduction and cancer.
  Journal
Mol Cell Endocrinol 434:166-75 (2016)
DOI:10.1016/j.mce.2016.06.027
Reference
PMID:22350867
  Authors
Dressing GE, Alyea R, Pang Y, Thomas P
  Title
Membrane progesterone receptors (mPRs) mediate progestin induced antimorbidity in breast cancer cells and are expressed in human breast tumors.
  Journal
Horm Cancer 3:101-12 (2012)
DOI:10.1007/s12672-012-0106-x
Reference
PMID:25819032
  Authors
Vares G, Sai S, Wang B, Fujimori A, Nenoi M, Nakajima T
  Title
Progesterone generates cancer stem cells through membrane progesterone receptor-triggered signaling in basal-like human mammary cells.
  Journal
Cancer Lett 362:167-73 (2015)
DOI:10.1016/j.canlet.2015.03.030
Reference
PMID:33014829
  Authors
Chen B, Ye P, Chen Y, Liu T, Cha JH, Yan X, Yang WH
  Title
Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance.
  Journal
Front Oncol 10:1657 (2020)
DOI:10.3389/fonc.2020.01657
Reference
PMID:29146555
  Authors
Boonyaratanakornkit V, Hamilton N, Marquez-Garban DC, Pateetin P, McGowan EM, Pietras RJ
  Title
Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer.
  Journal
Mol Cell Endocrinol 466:51-72 (2018)
DOI:10.1016/j.mce.2017.11.010
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