KEGG   NETWORK: N01358
Entry
N01358                      Network                                

Name
P4-PR-PI3K signaling pathway
Definition
P4 -> (PGR+SRC) -> PI3K -> PIP3 -> AKT
  Expanded
C00410 -> (5241+6714) -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling
Type
Reference
Gene
5241  PGR; progesterone receptor
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
C00410 (P4)  Progesterone
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Boonyaratanakornkit V, Hamilton N, Marquez-Garban DC, Pateetin P, McGowan EM, Pietras RJ
  Title
Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer.
  Journal
Mol Cell Endocrinol 466:51-72 (2018)
DOI:10.1016/j.mce.2017.11.010
Reference
  Authors
Pedroza DA, Subramani R, Lakshmanaswamy R
  Title
Classical and Non-Classical Progesterone Signaling in Breast Cancers.
  Journal
Cancers (Basel) 12:E2440 (2020)
DOI:10.3390/cancers12092440
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