| Entry |
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| Name |
P4/MPA to PR-PI3K signaling pathway
|
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| Definition |
(P4,MPA) -> (PGR+SRC) -> PI3K -> PIP3 -> AKT |
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| Expanded |
(C00410,C08150) -> (5241+6714) -> (5290,5291,5293) -> C05981 -> (207,208,10000) |
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| Class |
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| Type |
Env factor
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| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
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| Disease |
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| Gene |
| 5241 | PGR; progesterone receptor |
| 6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
|
|---|
| Perturbant |
| C08150 (MPA) | Medroxyprogesterone acetate |
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
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| Reference |
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| Authors |
Fu XD, Giretti MS, Baldacci C, Garibaldi S, Flamini M, Sanchez AM, Gadducci A, Genazzani AR, Simoncini T |
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| Title |
Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton. |
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| Journal |
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| Reference |
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| Authors |
Fu XD, Goglia L, Sanchez AM, Flamini M, Giretti MS, Tosi V, Genazzani AR, Simoncini T |
|---|
| Title |
Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase. |
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| Journal |
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| Reference |
|
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| Authors |
Wang HC, Lee WS |
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| Title |
Molecular mechanisms underlying progesterone-enhanced breast cancer cell migration. |
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| Journal |
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| LinkDB |
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