Entry Name Definition PhIP -- CYP1A2 >> SULT1A -> N-sulfonyloxy-PhIP == DNA
Expanded C16038 -- 1544 >> (6817,6799,6818,445329) -> C20288 == C00039
Class nt06250 DNA adduct formation (cancer)
Type Env factor
Pathway hsa05204 Chemical carcinogenesis - DNA adducts
Disease Gene 1544 CYP1A2; cytochrome P450 family 1 subfamily A member 2
6817 SULT1A1; sulfotransferase family 1A member 1
6799 SULT1A2; sulfotransferase family 1A member 2
6818 SULT1A3; sulfotransferase family 1A member 3
445329 SULT1A4; sulfotransferase family 1A member 4
Perturbant C16038 (PhIP) 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Metabolite Reference Authors Patterson AD, Gonzalez FJ, Idle JR
Title Xenobiotic metabolism: a view through the metabolometer.
Journal Reference Authors Androutsopoulos VP, Tsatsakis AM, Spandidos DA
Title Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.
Journal Reference Authors Kaderlik KR, Minchin RF, Mulder GJ, Ilett KF, Daugaard-Jenson M, Teitel CH, Kadlubar FF
Title Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues.
Journal Reference Authors Cheung C, Ma X, Krausz KW, Kimura S, Feigenbaum L, Dalton TP, Nebert DW, Idle JR, Gonzalez FJ
Title Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.
Journal LinkDB All DBs
