KEGG   NETWORK: N01371
Entry
N01371                      Network                                
Name
PhIP to DNA adducts
Definition
PhIP -- CYP1A2 >> SULT1A -> N-sulfonyloxy-PhIP == DNA
  Expanded
C16038 -- 1544 >> (6817,6799,6818,445329) -> C20288 == C00039
Class
nt06250 DNA adduct formation
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00031  Breast cancer
H00020  Colorectal cancer
Gene
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2
6817  SULT1A1; sulfotransferase family 1A member 1
6799  SULT1A2; sulfotransferase family 1A member 2
6818  SULT1A3; sulfotransferase family 1A member 3
445329  SULT1A4; sulfotransferase family 1A member 4
Perturbant
C16038 (PhIP)  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Metabolite
C20288  N-Sulfonyloxy-PhIP
C00039  DNA
Reference
  Authors
Patterson AD, Gonzalez FJ, Idle JR
  Title
Xenobiotic metabolism: a view through the metabolometer.
  Journal
Chem Res Toxicol 23:851-60 (2010)
DOI:10.1021/tx100020p
Reference
  Authors
Androutsopoulos VP, Tsatsakis AM, Spandidos DA
  Title
Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.
  Journal
BMC Cancer 9:187 (2009)
DOI:10.1186/1471-2407-9-187
Reference
PMID:8055652
  Authors
Kaderlik KR, Minchin RF, Mulder GJ, Ilett KF, Daugaard-Jenson M, Teitel CH, Kadlubar FF
  Title
Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues.
  Journal
Carcinogenesis 15:1703-9 (1994)
DOI:10.1093/carcin/15.8.1703
Reference
  Authors
Cheung C, Ma X, Krausz KW, Kimura S, Feigenbaum L, Dalton TP, Nebert DW, Idle JR, Gonzalez FJ
  Title
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.
  Journal
Chem Res Toxicol 18:1471-8 (2005)
DOI:10.1021/tx050136g
LinkDB

DBGET integrated database retrieval system