KEGG   NETWORK: N01402
Entry
N01402                      Network                                
Name
Manganese to electron transfer in Complex II
Definition
Mn2+ -| CxII -> QH2
  Expanded
C19610 -| (6389+6390+6391+6392) -> C00390
Class
nt06418 Oxidative phosphorylation
nt06460 Alzheimer disease
nt06463 Parkinson disease
Type
Env factor
Pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
Disease
H00056  Alzheimer disease
H00057  Parkinson disease
Gene
6389  SDHA; succinate dehydrogenase complex flavoprotein subunit A
6390  SDHB; succinate dehydrogenase complex iron sulfur subunit B
6391  SDHC; succinate dehydrogenase complex subunit C
6392  SDHD; succinate dehydrogenase complex subunit D
Perturbant
C19610 (Mn2+)  Manganese(2+)
Metabolite
C00390  Ubiquinol
Reference
  Authors
Martins AC Jr, Morcillo P, Ijomone OM, Venkataramani V, Harrison FE, Lee E, Bowman AB, Aschner M
  Title
New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease.
  Journal
Int J Environ Res Public Health 16:E3546 (2019)
DOI:10.3390/ijerph16193546
Reference
  Authors
Gunter TE, Gerstner B, Lester T, Wojtovich AP, Malecki J, Swarts SG, Brookes PS, Gavin CE, Gunter KK
  Title
An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays.
  Journal
Toxicol Appl Pharmacol 249:65-75 (2010)
DOI:10.1016/j.taap.2010.08.018
Reference
  Authors
Bonke E, Zwicker K, Drose S
  Title
Manganese ions induce H2O2 generation at the ubiquinone binding site of mitochondrial complex II.
  Journal
Arch Biochem Biophys 580:75-83 (2015)
DOI:10.1016/j.abb.2015.06.011
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