Entry |
|
Symbol |
SDHA, CMD1GG, FP, MC2DN1, NDAXOA, PGL5, PPGL5, SDH1, SDH2, SDHF
|
Name |
(RefSeq) succinate dehydrogenase complex flavoprotein subunit A
|
KO |
K00234 | succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1] |
|
Organism |
|
Pathway |
hsa04932 | Non-alcoholic fatty liver disease |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
Module |
hsa_M00011 | Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate |
|
Network |
|
Element |
N00988 | Electron transfer in Complex II |
N00989 | Mutation-caused aberrant Htt to electron transfer in Complex II |
N01392 | Arsenic to electron transfer in complex II |
N01393 | Arsenic to electron transfer in complex II |
N01402 | Manganese to electron transfer in Complex II |
N01617 | Citrate cycle, second carbon oxidation 2 |
N01691 | mitochondrial complex - UCP1 in Thermogenesis |
|
Disease |
H01022 | Diseases of the tricarboxylic acid cycle |
H02005 | Mitochondrial complex II deficiency |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
6389 (SDHA)
09102 Energy metabolism
00190 Oxidative phosphorylation
6389 (SDHA)
09150 Organismal Systems
09159 Environmental adaptation
04714 Thermogenesis
6389 (SDHA)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
6389 (SDHA)
09164 Neurodegenerative disease
05010 Alzheimer disease
6389 (SDHA)
05012 Parkinson disease
6389 (SDHA)
05014 Amyotrophic lateral sclerosis
6389 (SDHA)
05016 Huntington disease
6389 (SDHA)
05020 Prion disease
6389 (SDHA)
05022 Pathways of neurodegeneration - multiple diseases
6389 (SDHA)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
6389 (SDHA)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
6389 (SDHA)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.5 With a quinone or related compound as acceptor
1.3.5.1 succinate dehydrogenase
6389 (SDHA)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
5:218320..268746
|
AA seq |
664 aa
MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDH
EFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWR
WHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKF
GKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIE
DGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGI
YGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPE
KDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQ
VLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDK
VPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKIS
KLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVR
IDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPA
IRSY |
NT seq |
1995 nt +upstreamnt +downstreamnt
atgtcgggggtccggggcctgtcgcggctgctgagcgctcggcgcctggcgctggccaag
gcgtggccaacagtgttgcaaacaggaacccgaggttttcacttcactgttgatgggaac
aagagggcatctgctaaagtttcagattccatttctgctcagtatccagtagtggatcat
gaatttgatgcagtggtggtaggcgctggaggggcaggcttgcgagctgcatttggcctt
tctgaggcagggtttaatacagcatgtgttaccaagctgtttcctaccaggtcacacact
gttgcagcacagggaggaatcaatgctgctctggggaacatggaggaggacaactggagg
tggcatttctacgacaccgtgaagggctccgactggctgggggaccaggatgccatccac
tacatgacggagcaggcccccgccgccgtggtcgagctagaaaattatggcatgccgttt
agcagaactgaagatgggaagatttatcagcgtgcatttggtggacagagcctcaagttt
ggaaagggcgggcaggcccatcggtgctgctgtgtggctgatcggactggccactcgcta
ttgcacaccttatatggaaggtctctgcgatatgataccagctattttgtggagtatttt
gccttggatctcctgatggagaatggggagtgccgtggtgtcatcgcactgtgcatagag
gacgggtccatccatcgcataagagcaaagaacactgttgttgccacaggaggctacggg
cgcacctacttcagctgcacgtctgcccacaccagcactggcgacggcacggccatgatc
accagggcaggccttccttgccaggacctagagtttgttcagttccaccctacaggcata
tatggtgctggttgtctcattacggaaggatgtcgtggagagggaggcattctcattaac
agtcaaggcgaaaggtttatggagcgatacgcccctgtcgcgaaggacctggcgtctaga
gatgtggtgtctcggtccatgactctggagatccgagaaggaagaggctgtggccctgag
aaagatcacgtctacctgcagctgcaccacctacctccagagcagctggccacgcgcctg
cctggcatttcagagacagccatgatcttcgctggcgtggacgtcacgaaggagccgatc
cctgtcctccccaccgtgcattataacatgggcggcattcccaccaactacaaggggcag
gtcctgaggcacgtgaatggccaggatcagattgtgcccggcctgtacgcctgtggggag
gccgcctgtgcctcggtacatggtgccaaccgcctcggggcaaactcgctcttggacctg
gttgtctttggtcgggcatgtgccctgagcatcgaagagtcatgcaggcctggagataaa
gtccctccaattaaaccaaacgctggggaagaatctgtcatgaatcttgacaaattgaga
tttgctgatggaagcataagaacatcggaactgcgactcagcatgcagaagtcaatgcaa
aatcatgctgccgtgttccgtgtgggaagcgtgttgcaagaaggttgtgggaaaatcagc
aagctctatggagacctaaagcacctgaagacgttcgaccggggaatggtctggaacacg
gacctggtggagaccctggagctgcagaacctgatgctgtgtgcgctgcagaccatctac
ggagcagaggcacggaaggagtcacggggcgcgcatgccagggaagactacaaggtgcgg
attgatgagtacgattactccaagcccatccaggggcaacagaagaagccctttgaggag
cactggaggaagcacaccctgtcctatgtggacgttggcactgggaaggtcactctggaa
tatagacccgtgatcgacaaaactttgaacgaggctgactgtgccaccgtcccgccagcc
attcgctcctactga |