KEGG   NETWORK: N01409
Entry
N01409                      Network                                

Name
Metals to PI3K signaling pathway
Definition
Metals -> ROS -| PTEN -| PIP3 -> AKT
  Expanded
(C06269,C01413,C19171,C06268,C06696,C00023,C00291) -> C22381 -| 5728 -| C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00021  Renal cell carcinoma
H00024  Prostate cancer
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
H00048  Hepatocellular carcinoma
H00054  Nasopharyngeal cancer
Gene
5728  PTEN; phosphatase and tensin homolog
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
C06269 (Metals)  Arsenic
C01413 (Metals)  Cadmium
C19171 (Metals)  Cobalt
C06268 (Metals)  Chromium
C06696 (Metals)  Lead
C00023 (Metals)  Iron
C00291 (Metals)  Nickel
Metabolite
C22381  Reactive oxygen species
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Storz P
  Title
Reactive oxygen species in tumor progression.
  Journal
Front Biosci 10:1881-96 (2005)
DOI:10.2741/1667
Reference
  Authors
Moldogazieva NT, Lutsenko SV, Terentiev AA
  Title
Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy.
  Journal
Cancer Res 78:6040-6047 (2018)
DOI:10.1158/0008-5472.CAN-18-0980
Reference
  Authors
Liou GY, Storz P
  Title
Reactive oxygen species in cancer.
  Journal
Free Radic Res 44:479-96 (2010)
DOI:10.3109/10715761003667554
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