| Entry |
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| Name |
Paraquat to FAS-JNK signaling pathway
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| Definition |
PQ -> ROS -| TRX1 -| ASK1 -> JNK |
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| Expanded |
C14701 -> C22381 -| 7295 -| 4217 -> (5599,5601,5602) |
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| Class |
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| Type |
Env factor
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| Pathway |
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| Disease |
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| Gene |
| 4217 | MAP3K5; mitogen-activated protein kinase kinase kinase 5 |
| 5599 | MAPK8; mitogen-activated protein kinase 8 |
| 5601 | MAPK9; mitogen-activated protein kinase 9 |
| 5602 | MAPK10; mitogen-activated protein kinase 10 |
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| Perturbant |
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| Metabolite |
| C22381 | Reactive oxygen species |
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|---|
| Reference |
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| Authors |
Niso-Santano M, Gonzalez-Polo RA, Bravo-San Pedro JM, Gomez-Sanchez R, Lastres-Becker I, Ortiz-Ortiz MA, Soler G, Moran JM, Cuadrado A, Fuentes JM |
|---|
| Title |
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis. |
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| Journal |
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| Reference |
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| Authors |
Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B |
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| Title |
Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. |
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| Journal |
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| Reference |
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|---|
| Authors |
Dinis-Oliveira RJ, Remiao F, Carmo H, Duarte JA, Navarro AS, Bastos ML, Carvalho F |
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| Title |
Paraquat exposure as an etiological factor of Parkinson's disease. |
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| Journal |
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| LinkDB |
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