KEGG   NETWORK: N01467
Entry
N01467                      Network                                
Name
V(D)J recombination
Definition
RAG1+RAG2 -> Ku == DNAPKC -> DNAPK+ARTEMIS -> DNAPK+POLX -> DNAPK == LIG4+XRCC4+XLF
  Expanded
5896+5897 -> 2547+7520 == 5591 -> 2547+7520+5591+64421 -> (2547+7520+5591)+(27343,27434,1791) -> 2547+7520+5591 == 3981+7518+79840
Class
nt06506 Double-strand break repair
Type
Reference
Pathway
hsa03450  Non-homologous end-joining
Gene
5896  RAG1; recombination activating 1
5897  RAG2; recombination activating 2
2547  XRCC6; X-ray repair cross complementing 6
7520  XRCC5; X-ray repair cross complementing 5
5591  PRKDC; protein kinase, DNA-activated, catalytic subunit
64421  DCLRE1C; DNA cross-link repair 1C
27343  POLL; DNA polymerase lambda
27434  POLM; DNA polymerase mu
1791  DNTT; DNA nucleotidylexotransferase
3981  LIG4; DNA ligase 4
7518  XRCC4; X-ray repair cross complementing 4
79840  NHEJ1; non-homologous end joining factor 1
Reference
PMID:22569912
  Authors
Malu S, Malshetty V, Francis D, Cortes P
  Title
Role of non-homologous end joining in V(D)J recombination.
  Journal
Immunol Res 54:233-46 (2012)
DOI:10.1007/s12026-012-8329-z
Reference
PMID:25987660
  Authors
de Villartay JP
  Title
Congenital defects in V(D)J recombination.
  Journal
Br Med Bull 114:157-67 (2015)
DOI:10.1093/bmb/ldv020
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