Homo sapiens (human): 5424
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Entry
5424 CDS
T01001
Symbol
POLD1, CDC2, CRCS10, IMD120, MDPL, POLD
Name
(RefSeq) DNA polymerase delta 1, catalytic subunit
KO
K02327
DNA polymerase delta subunit 1 [EC:
2.7.7.7
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03030
DNA replication
hsa03410
Base excision repair
hsa03420
Nucleotide excision repair
hsa03430
Mismatch repair
hsa03440
Homologous recombination
Network
nt06502
Nucleotide excision repair
nt06503
Mismatch repair
nt06504
Base excision repair
nt06506
Double-strand break repair
nt06509
DNA replication
Element
N01431
Core NER reaction
N01432
Mismatch repair
N01436
Long patch BER
N01452
Homologous recombination
N01472
Okazaki fragment maturation
Disease
H00020
Colorectal cancer
H00093
Combined immunodeficiency
H01623
MDPL syndrome
H02568
Polymerase proofreading-associated polyposis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03030 DNA replication
5424 (POLD1)
03410 Base excision repair
5424 (POLD1)
03420 Nucleotide excision repair
5424 (POLD1)
03430 Mismatch repair
5424 (POLD1)
03440 Homologous recombination
5424 (POLD1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
hsa03032
]
5424 (POLD1)
03400 DNA repair and recombination proteins [BR:
hsa03400
]
5424 (POLD1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.7 DNA-directed DNA polymerase
5424 (POLD1)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Replication Elongation Factors
DNA polymerase delta complex
5424 (POLD1)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
SSBR (single strand breaks repair)
BER (base exicision repair)
Long Patch-BER factors
DNA polymerase delta complex
5424 (POLD1)
MMR (mismatch excision repair)
DNA polymerase delta complex
5424 (POLD1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DNA_pol_B
DNA_pol_B_exo1
zf-C4pol
DNA_pol_B_2
Motif
Other DBs
NCBI-GeneID:
5424
NCBI-ProteinID:
NP_001243778
OMIM:
174761
HGNC:
9175
Ensembl:
ENSG00000062822
Pharos:
P28340
(Tclin)
UniProt:
P28340
Structure
PDB
PDBj
LinkDB
All DBs
Position
19:50384323..50418018
Genome browser
AA seq
1107 aa
AA seq
DB search
MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
MRKKVRKDLEDQEQLLRRFGPPGPEAW
NT seq
3324 nt
NT seq
+upstream
nt +downstream
nt
atggatggcaagcggcggccaggcccagggcccggggtgcccccaaagcgggcccgtggg
ggcctctgggatgatgatgatgcacctcggccatcccaattcgaggaggacctggcactg
atggaggagatggaggcagaacacaggctgcaggagcaggaggaggaggagctgcagtca
gtcctggagggggttgcagacgggcaggtcccaccatcagccatagatcctcgctggctt
cggcccacaccaccagcgctggacccccagacagagcccctcatcttccaacagttggag
attgaccattatgtgggcccagcgcagcctgtgcctggggggcccccaccatcccgcggc
tccgtgcctgtgctccgcgccttcggggtcaccgatgaggggttctctgtctgctgccac
atccacggcttcgctccctacttctacaccccagcgccccctggtttcgggcccgagcac
atgggtgacctgcaacgggagctgaacttggccatcagccgggacagtcgcggggggagg
gagctgactgggccggccgtgctggctgtggaactgtgctcccgagagagcatgtttggg
taccacgggcacggcccctccccgttcctgcgcatcaccgtggcgctgccgcgcctcgtg
gccccggcccgccgtctcctggaacagggcatccgtgtggcaggcctgggcacgcccagc
ttcgcgccctacgaggccaacgtcgactttgagatccggttcatggtggacacggacatc
gtcggctgcaactggctggagctcccagctgggaaatacgccctgaggctgaaggagaag
gctacgcagtgccagctggaggcggacgtgctgtggtctgacgtggtcagtcacccaccg
gaagggccatggcagcgcattgcgcccttgcgcgtgctcagcttcgatatcgagtgcgcc
ggccgcaaaggcatcttccctgagcctgagcgggaccctgtcatccagatctgctcgctg
ggcctgcgctggggggagccggagcccttcctacgcctggcgctcaccctgcggccctgt
gcccccatcctgggtgccaaggtgcagagctacgagaaggaggaggacctgctgcaggcc
tggtccaccttcatccgtatcatggaccccgacgtgatcaccggttacaacatccagaac
ttcgaccttccgtacctcatctctcgggcccagaccctcaaggtacaaacattccctttc
ctgggccgtgtggccggcctttgctccaacatccgggactcttcattccagtccaagcag
acgggccggcgggacaccaaggttgtcagcatggtgggccgcgtgcagatggacatgctg
caggtgctgctgcgggagtacaagctccgctcctacacgctcaatgccgtgagcttccac
ttcctgggcgagcagaaggaggacgtgcagcacagcatcatcaccgacctgcagaatggg
aacgaccagacccgccgccgcctggctgtgtactgcctgaaggatgcctacctgccactg
cggctgctggagcggctcatggtgctggtgaacgccgtggagatggcgagggtcactggc
gtgcccctcagctacctgctcagtcgtggccagcaggtcaaggtcgtatcccagctgttg
cggcaggccatgcacgaggggctgctgatgcccgtggtgaagtcagagggcggcgaggac
tacacgggagccactgtcatcgagcccctcaaagggtactacgacgtccccatcgccacc
ctggacttctcctcgctgtacccgtccatcatgatggcccacaacctgtgttacaccacg
ctccttcggcccgggactgcacagaaactgggcctgactgaggatcagttcatcaggacc
cccaccggggacgagtttgtgaagacctcagtgcggaaggggctgctgccccagatcctg
gagaacctgctcagtgcccggaagagggccaaggccgagctggccaaggagacagacccc
ctccggcgccaggtcctggatggacggcagctggcgctgaaggtgagcgccaactccgta
tacggcttcactggcgcccaggtgggcaagttgccgtgcctggagatctcacagagcgtc
acggggttcggacgtcagatgatcgagaaaaccaagcagctggtggagtctaagtacaca
gtggagaatggctacagcaccagtgccaaggtggtgtatggtgacactgactccgtcatg
tgccgattcggcgtgtcctcggtggctgaggcgatggccctggggcgggaggccgcggac
tgggtgtcaggtcacttcccgtcgcccatccggctggagtttgagaaggtctacttccca
tacctgcttatcagcaagaagcgctacgcgggcctgctcttctcctcccggcccgacgcc
cacgaccgcatggactgcaagggcctggaggccgtgcgcagggacaactgccccctcgtg
gccaacctggtcactgcctcactgcgccgcctgctcatcgaccgagaccctgagggcgcg
gtggctcacgcacaggacgtcatctcggacctgctgtgcaaccgcatcgatatctcccag
ctggtcatcaccaaggagctgacccgcgcggcctccgactatgccggcaagcaggcccac
gtggagctggccgagaggatgaggaagcgggaccccgggagtgcgcccagcctgggcgac
cgcgtcccctacgtgatcatcagtgccgccaagggtgtggccgcctacatgaagtcggag
gacccgctgttcgtgctggagcacagcctgcccattgacacgcagtactacctggagcag
cagctggccaagcccctcctgcgcatcttcgagcccatcctgggcgagggccgtgccgag
gctgtgctactgcggggggaccacacgcgctgcaagacggtgctcacgggcaaggtgggc
ggcctcctggccttcgccaaacgccgcaactgctgcattggctgccgcacagtgctcagc
caccagggagccgtgtgtgagttctgccagccccgggagtctgagctgtatcagaaggag
gtatcccatctgaatgccctggaggagcgcttctcgcgcctctggacgcagtgccagcgc
tgccagggcagcctgcacgaggacgtcatctgcaccagccgggactgccccatcttctac
atgcgcaagaaggtgcggaaggacctggaagaccaggagcagctcctgcggcgcttcgga
ccccctggacctgaggcctggtga
DBGET
integrated database retrieval system
