Homo sapiens (human): 1763
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Entry
1763 CDS
T01001
Symbol
DNA2, DNA2L, RTS4, hDNA2
Name
(RefSeq) DNA replication ATP-dependent helicase/nuclease DNA2
KO
K10742
DNA replication ATP-dependent helicase/nuclease Dna2 [EC:
5.6.2.3
3.1.-.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03030
DNA replication
Network
nt06506
Double-strand break repair
nt06509
DNA replication
Element
N01446
DNA end resection and RPA loading
N01472
Okazaki fragment maturation
Disease
H00992
Seckel syndrome
H01118
Progressive external ophthalmoplegia
H01734
Rothmund-Thomson syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03030 DNA replication
1763 (DNA2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
hsa03032
]
1763 (DNA2)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.3 DNA 5'-3' helicase
1763 (DNA2)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Replication Elongation Factors
Other elongation factors
1763 (DNA2)
Prokaryotic type
Elongation factors (archaeal)
Other elongation factors
1763 (DNA2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Dna2
AAA_12
Dna2_Rift
AAA_11
AAA_30
AAA_19
nSTAND3
UvrD-helicase
SRP54
bpMoxR
DEAD
Cas_Cas4
ResIII
AAA_25
CbiA
SLFN-g3_helicase
MobB
UvrD_C_2
AAA_22
AAA_7
NAT10_TcmA_helicase
PhoH
AAA
AAA_29
Motif
Other DBs
NCBI-GeneID:
1763
NCBI-ProteinID:
NP_001073918
OMIM:
601810
HGNC:
2939
Ensembl:
ENSP00000351185.3
UniProt:
P51530
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:complement(68414064..68472521)
Genome browser
AA seq
1060 aa
AA seq
DB search
MEQLNELELLMEKSFWEEAELPAELFQKKVVASFPRTVLSTGMDNRYLVLAVNTVQNKEG
NCEKRLVITASQSLENKELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILY
PDMLISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQ
ELAFQTIQEIRHLKEMYRLNLSQDEIKQEVEDYLPSFCKWAGDFMHKNTSTDFPQMQLSL
PSDNSKDNSTCNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYKIMPLELK
TGKESNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVPANHLDKRELLKLRNQ
MAFSLFHRISKSATRQKTQLASLPQIIEEEKTCKYCSQIGNCALYSRAVEQQMDCSSVPI
VMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSCIG
NLIRMEHVKIVCDGQYLHNFQCKHGAIPVTNLMAGDRVIVSGEERSLFALSRGYVKEINM
TTVTCLLDRNLSVLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTFVSKKLRDLIIDFRE
PQFISYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICT
LVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPAIQQFTEQEICRS
KSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQISQPICLGPLFFSR
RFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKSAVVQLTVQYRMNSKIMSLSNKL
TYEGKLECGSDKVANAVINLRHFKDVKLELEFYADYSDNPWLMGVFEPNNPVCFLNTDKV
PAPEQVEKGGVSNVTEAKLIVFLTSIFVKAGCSPSDIGIIAPYRQQLKIINDLLARSIGM
VEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLKDWRRLNVAITRAKHKLILLGCVPSL
NCYPPLEKLLNHLNSEKLIIDLPSREHESLCHILGDFQRE
NT seq
3183 nt
NT seq
+upstream
nt +downstream
nt
atggagcagctgaacgaactggagctgctgatggagaagagtttttgggaggaggcggag
ctgccggcggagctatttcagaagaaagtggtagcttcctttccaagaacagttctgagc
acaggaatggataaccggtacctggtgttggcagtcaatactgtacagaacaaagaggga
aactgtgaaaagcgcctggtcatcactgcttcacagtcactagaaaataaagaactatgc
atccttaggaatgactggtgttctgttccagtagagccaggagatatcattcatttggag
ggagactgcacatctgacacttggataatagataaagattttggatatttgattctgtat
ccagacatgctgatttctggcaccagcatagccagtagtattcgatgtatgagaagagct
gtcctgagtgaaacttttaggagctctgatccagccacacgccaaatgctaattggtacg
gttctccatgaggtgtttcaaaaagccataaataatagctttgccccagaaaagctacaa
gaacttgcttttcaaacaattcaagaaataagacatttgaaggaaatgtaccgcttaaat
ctaagtcaagatgaaataaaacaagaagtagaggactatcttccttcgttttgtaaatgg
gcaggagatttcatgcataaaaacacttcgactgacttccctcagatgcagctctctctg
ccaagtgataatagtaaggataattcaacatgtaacattgaagtcgtgaaaccaatggat
attgaagaaagcatttggtcccctaggtttggattgaaaggcaaaatagatgttacagtt
ggtgtgaaaatacatcgagggtataaaacaaaatacaagataatgccgctggaacttaaa
actggcaaagaatcaaattctattgaacaccgtagtcaggttgttctgtacactctacta
agccaagagagaagagctgatccagaggctggcttgcttctctacctcaagactggtcag
atgtaccctgtgcctgccaaccatctagataaaagagaattattaaagctaagaaaccag
atggcattctcattgtttcaccgtattagcaaatctgctactagacagaagacacagctt
gcttctttgccacaaataattgaggaagagaaaacttgtaaatattgttcacaaattggc
aattgtgctctttatagcagagcagttgaacaacagatggattgtagttcagtcccaatt
gtgatgctgcccaaaatagaagaagaaacccagcatctgaagcaaacacacttagaatat
ttcagcctttggtgtctaatgttaaccctggagtcacaatcgaaggataataaaaagaat
caccaaaatatctggctaatgcctgcttcggaaatggagaagagtggcagttgcattgga
aacctgattagaatggaacatgtaaagatagtttgtgatgggcaatatttacataatttc
caatgtaaacatggtgccatacctgtcacaaatctaatggcaggtgacagagttattgta
agtggagaagaaaggtcactgtttgctttgtctagaggatatgtgaaggagattaacatg
acaacagtaacttgtttattagacagaaacttgtcggtccttccagaatcaactttgttc
agattagaccaagaagaaaaaaattgtgatatagataccccattaggaaatctttccaaa
ttgatggaaaacacgtttgtcagcaaaaaacttcgagatttaattattgactttcgtgaa
cctcagtttatatcctaccttagttctgttcttccacatgatgcaaaggatacagttgcc
tgcattctaaagggtttgaataagcctcagaggcaagcgatgaaaaaggtacttctttca
aaagactacacactcatcgtgggtatgcctgggacaggaaaaacaactacgatatgtact
ctcgtaagaattctctacgcctgtggttttagcgttttgttgaccagctatacacactct
gctgttgacaatattcttttgaagttagccaagtttaaaataggatttttgcgtttgggt
cagattcagaaggttcatccagctatccagcaatttacagagcaagaaatttgcagatca
aagtccattaaatccttagctcttctagaagaactctacaatagtcaacttatagttgca
acaacatgtatgggaataaaccatccaatattttcccgtaaaatttttgatttttgtatt
gtggatgaagcctctcaaattagccaaccaatttgtctgggccccctttttttttcacgg
agatttgtgttagtgggggaccatcagcagcttcctcccctggtgctaaaccgtgaagca
agagctcttggcatgagtgaaagcttattcaagaggctggagcagaataagagtgctgtt
gtacagttaaccgtgcagtacagaatgaacagtaaaattatgtccttaagtaataagctg
acctatgagggcaagctggagtgtggatcagacaaagtggccaatgcagtgataaaccta
cgtcactttaaagatgtgaagctggaactggaattttatgctgactattctgataatcct
tggttgatgggagtatttgaacccaacaatcctgtttgtttccttaatacagacaaggtt
ccagcgccagaacaagttgaaaaaggtggtgtgagcaatgtaacagaagccaaactcata
gttttcctaacctccatttttgttaaggctggatgcagtccctctgatattggtattatt
gcaccgtacaggcagcaattaaagatcatcaatgatttattggcacgttctattgggatg
gtcgaagttaatacagtagacaaataccaaggaagggacaaaagtattgtcctagtatct
tttgttagaagtaataaggatggaactgttggtgaactcttgaaagattggcgacgtctt
aatgttgctataaccagagccaaacataaactgattcttctggggtgtgtgccctcacta
aattgctatcctcctttggagaagctgcttaatcatttaaactcagaaaaattaatcatt
gatcttccatcaagagaacatgaaagtctttgccacatattgggtgactttcaaagagaa
taa
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