KEGG   NETWORK: N01474
Entry
N01474                      Network                                
Name
TRAIP-dependent replisome disassembly
Definition
CMG+TRAIP -> CMG == MCM7+Ub -> MCM7+VCP+UFD1+NPL4
  Expanded
8318+4171+4172+4173+4174+4175+4176+9837+51659+64785+84296+10293 -> 8318+4171+4172+4173+4174+4175+9837+51659+64785+84296 == 4176+7314 -> 4176+7415+7353+55666
Class
nt06509 DNA replication
Type
Reference
Gene
8318  CDC45; cell division cycle 45
4171  MCM2; minichromosome maintenance complex component 2
4172  MCM3; minichromosome maintenance complex component 3
4173  MCM4; minichromosome maintenance complex component 4
4174  MCM5; minichromosome maintenance complex component 5
4175  MCM6; minichromosome maintenance complex component 6
4176  MCM7; minichromosome maintenance complex component 7
9837  GINS1; GINS complex subunit 1
51659  GINS2; GINS complex subunit 2
64785  GINS3; GINS complex subunit 3
84296  GINS4; GINS complex subunit 4
10293  TRAIP; TRAF interacting protein
7314  UBB; ubiquitin B
7415  VCP; valosin containing protein
7353  UFD1; ubiquitin recognition factor in ER associated degradation 1
55666  NPLOC4; NPL4 homolog, ubiquitin recognition factor
Reference
  Authors
Moreno SP, Gambus A
  Title
Mechanisms of eukaryotic replisome disassembly.
  Journal
Biochem Soc Trans 48:823-836 (2020)
DOI:10.1042/BST20190363
Reference
  Authors
Villa F, Fujisawa R, Ainsworth J, Nishimura K, Lie-A-Ling M, Lacaud G, Labib KP
  Title
CUL2(LRR1) , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle.
  Journal
EMBO Rep 22:e52164 (2021)
DOI:10.15252/embr.202052164
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