KEGG T01001: 7314

Homo sapiens (human): 7314

Entry

7314              CDS       T01001

Symbol

UBB, HEL-S-50

Name

(RefSeq) ubiquitin B

K04551

ubiquitin B

Organism

hsa Homo sapiens (human)

Pathway

hsa04120

Ubiquitin mediated proteolysis

hsa04137

Mitophagy - animal

hsa04140

Autophagy - animal

hsa05012

Parkinson disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05131

Shigellosis

hsa05167

Kaposi sarcoma-associated herpesvirus infection

Network

nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
nt06509  DNA replication
nt06523  Epigenetic regulation by Polycomb complexes
nt06532  Autophagy

Element

N01027

UCHL1-mediated hydrolysis

N01028

Mutation-inactivated UCHL1 to UCHL1-mediated hydrolysis

N01029

26S proteasome-mediated protein degradation

N01144

Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation

N01145

Mutation-inactivated VCP to 26S proteasome-mediated protein degradation

N01146

Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation

N01464

Fanconi anemia pathway

N01465

Lesion bypass by TLS and DSB formation

N01466

Homologous recombination in ICLR

N01473

DNA replication termination

N01474

TRAIP-dependent replisome disassembly

N01577

Gene silencing by methylation of H3K27 and ubiquitination of H2AK119

N01586

Activation of PRC2.2 by ubiquitination of H2AK119

N01614

Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes

N01636

Loading of the SMC5-SMC6 complex

N01716

Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    7314 (UBB)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    7314 (UBB)
   04137 Mitophagy - animal
    7314 (UBB)
09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    7314 (UBB)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    7314 (UBB)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    7314 (UBB)
   05022 Pathways of neurodegeneration - multiple diseases
    7314 (UBB)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7314 (UBB)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7314 (UBB)
Ubiquitin system [BR:hsa04121]
Ubiquitins and ubiquitin-like proteins
  Ubiquitins
   7314 (UBB)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of breast milk
   7314 (UBB)
  Exosomal proteins of other body fluids (saliva and urine)
   7314 (UBB)
  Exosomal proteins of colorectal cancer cells
   7314 (UBB)
  Exosomal proteins of bladder cancer cells
   7314 (UBB)

SSDB

Motif

Pfam:

ubiquitin Rad60-SLD Ubiquitin_2 DUF2604 Rad60-SLD_2 TBK1_ULD Ubiquitin_5 OTU1_UBXL Dsc3_N

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

17:16380779..16382745

AA seq 229 aa
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKA
KIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC

NT seq 690 nt +upstreamnt +downstreamnt
atgcagatcttcgtgaaaacccttaccggcaagaccatcacccttgaggtggagcccagt
gacaccatcgaaaatgtgaaggccaagatccaggataaggaaggcattccccccgaccag
cagaggctcatctttgcaggcaagcagctggaagatggccgtactctttctgactacaac
atccagaaggagtcgaccctgcacctggtcctgcgtctgagaggtggtatgcagatcttc
gtgaagaccctgaccggcaagaccatcaccctggaagtggagcccagtgacaccatcgaa
aatgtgaaggccaagatccaggataaagaaggcatccctcccgaccagcagaggctcatc
tttgcaggcaagcagctggaagatggccgcactctttctgactacaacatccagaaggag
tcgaccctgcacctggtcctgcgtctgagaggtggtatgcagatcttcgtgaagaccctg
accggcaagaccatcactctggaggtggagcccagtgacaccatcgaaaatgtgaaggcc
aagatccaagataaagaaggcatcccccccgaccagcagaggctcatctttgcaggcaag
cagctggaagatggccgcactctttctgactacaacatccagaaagagtcgaccctgcac
ctggtcctgcgcctgaggggtggctgttaa

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