KEGG   NETWORK: N01487
Entry
N01487                      Network                                
Name
Classical pathway of complement cascade, C4/C2 to C3 convertase formation
Definition
[C4,C2] -- ((C1QA,C1QB,C1QC)+C1R+C1S) -> [C4b,C2a] -> (C4b+C2a)
  Expanded
[(720,721),717] -- ((712,713,714)+715+716) -> [C22542,C22531] -> (C22542+C22531)
Class
nt06513 Complement cascade
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04610  Complement and coagulation cascades
Gene
720  C4A; complement C4A (Rodgers blood group)
721  C4B; complement C4B (Chido blood group)
717  C2; complement C2
712  C1QA; complement C1q A chain
713  C1QB; complement C1q B chain
714  C1QC; complement C1q C chain
715  C1R; complement C1r
716  C1S; complement C1s
Metabolite
C22542  Complement component 4b
C22531  Complement component 2a
Reference
  Authors
Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT
  Title
Complement System Part I - Molecular Mechanisms of Activation and Regulation.
  Journal
Front Immunol 6:262 (2015)
DOI:10.3389/fimmu.2015.00262
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