Homo sapiens (human): 717
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Entry
717 CDS
T01001
Symbol
C2, ARMD14, CO2
Name
(RefSeq) complement C2
KO
K01332
complement component 2 [EC:
3.4.21.43
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04610
Complement and coagulation cascades
hsa04936
Alcoholic liver disease
hsa05133
Pertussis
hsa05150
Staphylococcus aureus infection
hsa05171
Coronavirus disease - COVID-19
hsa05322
Systemic lupus erythematosus
Network
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06513
Complement cascade
Element
N01487
Classical pathway of complement cascade, C4/C2 to C3 convertase formation
N01491
Lectin pathway of complement cascade, C4/C2 to C3 convertase formation
Disease
H00080
Systemic lupus erythematosus
H00102
Classic complement pathway component defects
H00821
Age-related macular degeneration
Drug target
Empasiprubart:
D12992
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
717 (C2)
09160 Human Diseases
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
717 (C2)
09171 Infectious disease: bacterial
05133 Pertussis
717 (C2)
05150 Staphylococcus aureus infection
717 (C2)
09163 Immune disease
05322 Systemic lupus erythematosus
717 (C2)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
717 (C2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
717 (C2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.43 classical-complement-pathway C3/C5 convertase
717 (C2)
Peptidases and inhibitors [BR:
hsa01002
]
Serine peptidases
Family S1: chymotrypsin family
717 (C2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Trypsin
VWA
Sushi
VWA_2
DUF1986
HRM
Trypsin_2
Androglobin_IV
Motif
Other DBs
NCBI-GeneID:
717
NCBI-ProteinID:
NP_000054
OMIM:
613927
HGNC:
1248
Ensembl:
ENSG00000166278
CPD:
C22532
C22531
UniProt:
P06681
Q5JP69
Q53HP3
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:31897783..31945672
Genome browser
AA seq
752 aa
AA seq
DB search
MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA
SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG
FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN
LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES
LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS
EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME
TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW
RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW
HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI
SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC
RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT
DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS
KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
NT seq
2259 nt
NT seq
+upstream
nt +downstream
nt
atgggcccactgatggttcttttttgcctgctgttcctgtacccaggtctggcagactcg
gctccctcctgccctcagaacgtgaatatctcgggtggcaccttcaccctcagccatggc
tgggctcctgggagccttctcacctactcctgcccccagggcctgtacccatccccagca
tcacggctgtgcaagagcagcggacagtggcagaccccaggagccacccggtctctgtct
aaggcggtctgcaaacctgtgcgctgtccagcccctgtctcctttgagaatggcatttat
accccacggctggggtcctatcccgtgggtggcaatgtgagcttcgagtgtgaggatggc
ttcatattgcggggctcgcctgtgcgtcagtgtcgccccaacggcatgtgggatggagaa
acagctgtgtgtgataatggggctggccactgccccaacccaggcatttcactgggcgca
gtgcggacaggcttccgctttggtcatggggacaaggtccgctatcgctgctcctcgaat
cttgtgctcacggggtcttcggagcgggagtgccagggcaacggggtctggagtggaacg
gagcccatctgccgccaaccctactcttatgacttccctgaggacgtggcccctgccctg
ggcacttccttctcccacatgcttggggccaccaatcccacccagaagacaaaggaaagc
ctgggccgtaaaatccaaatccagcgctctggtcatctgaacctctacctgctcctggac
tgttcgcagagtgtgtcggaaaatgactttctcatcttcaaggagagcgcctccctcatg
gtggacaggatcttcagctttgagatcaatgtgagcgttgccattatcacctttgcctca
gagcccaaagtcctcatgtctgtcctgaacgacaactcccgggatatgactgaggtgatc
agcagcctggaaaatgccaactataaagatcatgaaaatggaactgggactaacacctat
gcggccttaaacagtgtctatctcatgatgaacaaccaaatgcgactcctcggcatggaa
acgatggcctggcaggaaatccgacatgccatcatccttctgacagatggaaagtccaat
atgggtggctctcccaagacagctgttgaccatatcagagagatcctgaacatcaaccag
aagaggaatgactatctggacatctatgccatcggggtgggcaagctggatgtggactgg
agagaactgaatgagctagggtccaagaaggatggtgagaggcatgccttcattctgcag
gacacaaaggctctgcaccaggtctttgaacatatgctggatgtctccaagctcacagac
accatctgcggggtggggaacatgtcagcaaacgcctctgaccaggagaggacaccctgg
catgtcactattaagcccaagagccaagagacctgccggggggccctcatctccgaccaa
tgggtcctgacagcagctcattgcttccgcgatggcaacgaccactccctgtggagggtc
aatgtgggagaccccaaatcccagtggggcaaagaattccttattgagaaggcggtgatc
tccccagggtttgatgtctttgccaaaaagaaccagggaatcctggagttctatggtgat
gacatagctctgctgaagctggcccagaaagtaaagatgtccacccatgccaggcccatc
tgccttccctgcacgatggaggccaatctggctctgcggagacctcaaggcagcacctgt
agggaccatgagaatgaactgctgaacaaacagagtgttcctgctcattttgtcgccttg
aatgggagcaaactgaacattaaccttaagatgggagtggagtggacaagctgtgccgag
gttgtctcccaagaaaaaaccatgttccccaacttgacagatgtcagggaggtggtgaca
gaccagttcctatgcagtgggacccaggaggatgagagtccctgcaagggagaatctggg
ggagcagttttccttgagcggagattcaggttttttcaggtgggtctggtgagctggggt
ctttacaacccctgccttggctctgctgacaaaaactcccgcaaaagggcccctcgtagc
aaggtcccgccgccacgagactttcacatcaatctcttccgcatgcagccctggctgagg
cagcacctgggggatgtcctgaattttttacccctctag
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