KEGG   NETWORK: N01555
Entry
N01555                      Network                                
Name
Hormone-like-cytokine to Jak-STAT signaling pathway
Definition
(EPO,GH,PRL,THPO,CSF3,LEP) -> (EPOR,GHR,PRLR,MPL,CSF3R,LEPR) -> JAK2 -> (STAT5A,STAT5B,STAT3)
  Expanded
(2056,(2688,2689),5617,7066,1440,3952) -> (2057,2690,5618,4352,1441,3953) -> 3717 -> (6776,6777,6774)
Class
nt06518 JAK-STAT signaling
Type
Reference
Pathway
hsa04630  JAK-STAT signaling pathway
Gene
2056  EPO; erythropoietin
2688  GH1; growth hormone 1
2689  GH2; growth hormone 2
5617  PRL; prolactin
7066  THPO; thrombopoietin
1440  CSF3; colony stimulating factor 3
3952  LEP; leptin
2057  EPOR; erythropoietin receptor
2690  GHR; growth hormone receptor
5618  PRLR; prolactin receptor
4352  MPL; MPL proto-oncogene, thrombopoietin receptor
1441  CSF3R; colony stimulating factor 3 receptor
3953  LEPR; leptin receptor
3717  JAK2; Janus kinase 2
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
6774  STAT3; signal transducer and activator of transcription 3
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
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