KEGG   Homo sapiens (human): 3157
Entry
3157              CDS       T01001                                 
Symbol
HMGCS1, HMGCS
Name
(RefSeq) 3-hydroxy-3-methylglutaryl-CoA synthase 1
  KO
K01641  hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00280  Valine, leucine and isoleucine degradation
hsa00650  Butanoate metabolism
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
hsa03320  PPAR signaling pathway
Module
hsa_M00095  C5 isoprenoid biosynthesis, mevalonate pathway
Network
nt06034  Cholesterol biosynthesis
  Element
N01635  Mevalonate pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    3157 (HMGCS1)
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    3157 (HMGCS1)
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    3157 (HMGCS1)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    3157 (HMGCS1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.10  hydroxymethylglutaryl-CoA synthase
     3157 (HMGCS1)
SSDB
Motif
Pfam: HMG_CoA_synt_C HMG_CoA_synt_N Cullin PS_Dcarbxylase
Other DBs
NCBI-GeneID: 3157
NCBI-ProteinID: NP_001091742
OMIM: 142940
HGNC: 5007
Ensembl: ENSG00000112972
UniProt: Q01581
Structure
LinkDB
Position
5:complement(43287470..43313412)
AA seq 520 aa
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
NT seq 1563 nt   +upstreamnt  +downstreamnt
atgcctggatcacttcctttgaatgcagaagcttgctggccaaaagatgtgggaattgtt
gcccttgagatctattttccttctcaatatgttgatcaagcagagttggaaaaatatgat
ggtgtagatgctggaaagtataccattggcttgggccaggccaagatgggcttctgcaca
gatagagaagatattaactctctttgcatgactgtggttcagaatcttatggagagaaat
aacctttcctatgattgcattgggcggctggaagttggaacagagacaatcatcgacaaa
tcaaagtctgtgaagactaatttgatgcagctgtttgaagagtctgggaatacagatata
gaaggaatcgacacaactaatgcatgctatggaggcacagctgctgtcttcaatgctgtt
aactggattgagtccagctcttgggatggacggtatgccctggtagttgcaggagatatt
gctgtatatgccacaggaaatgctagacctacaggtggagttggagcagtagctctgcta
attgggccaaatgctcctttaatttttgaacgagggcttcgtgggacacatatgcaacat
gcctatgatttttacaagcctgatatgctatctgaatatcctatagtagatggaaaactc
tccatacagtgctacctcagtgcattagaccgctgctattctgtctactgcaaaaagatc
catgcccagtggcagaaagagggaaatgataaagattttaccttgaatgattttggcttc
atgatctttcactcaccatattgtaaactggttcagaaatctctagctcggatgttgctg
aatgacttccttaatgaccagaatagagataaaaatagtatctatagtggcctggaagcc
tttggggatgttaaattagaagacacctactttgatagagatgtggagaaggcatttatg
aaggctagctctgaactcttcagtcagaaaacaaaggcatctttacttgtatcaaatcaa
aatggaaatatgtacacatcttcagtatatggttcccttgcatctgttctagcacagtac
tcacctcagcaattagcagggaagagaattggagtgttttcttatggttctggtttggct
gccactctgtactctcttaaagtcacacaagatgctacaccggggtctgctcttgataaa
ataacagcaagtttatgtgatcttaaatcaaggcttgattcaagaactggtgtggcacca
gatgtcttcgctgaaaacatgaagctcagagaggacacccatcatttggtcaactatatt
ccccagggttcaatagattcactctttgaaggaacgtggtacttagttagggtggatgaa
aagcacagaagaacttacgctcggcgtcccactccaaatgatgacactttggatgaagga
gtaggacttgtgcattcaaacatagcaactgagcatattccaagccctgccaagaaagta
ccaagactccctgccacagcagcagaacctgaagcagctgtcattagtaatggggaacat
taa

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