| Entry |
|
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| Name |
ICOSLG/ICOS-PI3K signaling pathway
|
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| Definition |
ICOSLG -> ICOS -> PI3Kdelta -> PIP3 -> AKT |
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| Expanded |
23308 -> 29851 -> (5293+(5295,5296,8503)) -> C05981 -> (207,208,10000) |
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| Class |
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| Type |
Reference
|
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| Pathway |
| hsa04660 | T cell receptor signaling pathway |
|
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| Gene |
| 23308 | ICOSLG; inducible T cell costimulator ligand |
| 29851 | ICOS; inducible T cell costimulator |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 5295 | PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 |
| 5296 | PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 |
| 8503 | PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
|
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
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| Reference |
|
|---|
| Authors |
Chen L, Flies DB |
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| Title |
Molecular mechanisms of T cell co-stimulation and co-inhibition. |
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| Journal |
|
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| Reference |
|
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| Authors |
Buchanan CM, Lee KL, Shepherd PR |
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| Title |
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Wikenheiser DJ, Stumhofer JS |
|---|
| Title |
ICOS Co-Stimulation: Friend or Foe? |
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| Journal |
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| LinkDB |
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