KEGG   Homo sapiens (human): 8503
Entry
8503              CDS       T01001                                 
Symbol
PIK3R3, p55, p55-GAMMA, p55PIK
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 3
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04081  Hormone signaling
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06325  Hormone/cytokine signaling
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
  Element
N01165  PDL/PD1-SHP-PI3K signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01695  BCR-BCAP/CD19-PI3K signaling pathway
N01696  ICOSLG/ICOS-PI3K signaling pathway
N01708  INS-AKT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    8503 (PIK3R3)
   04015 Rap1 signaling pathway
    8503 (PIK3R3)
   04630 JAK-STAT signaling pathway
    8503 (PIK3R3)
   04668 TNF signaling pathway
    8503 (PIK3R3)
   04066 HIF-1 signaling pathway
    8503 (PIK3R3)
   04068 FoxO signaling pathway
    8503 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    8503 (PIK3R3)
   04072 Phospholipase D signaling pathway
    8503 (PIK3R3)
   04071 Sphingolipid signaling pathway
    8503 (PIK3R3)
   04024 cAMP signaling pathway
    8503 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    8503 (PIK3R3)
   04152 AMPK signaling pathway
    8503 (PIK3R3)
   04150 mTOR signaling pathway
    8503 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    8503 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    8503 (PIK3R3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    8503 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    8503 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    8503 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    8503 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    8503 (PIK3R3)
   04660 T cell receptor signaling pathway
    8503 (PIK3R3)
   04662 B cell receptor signaling pathway
    8503 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    8503 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    8503 (PIK3R3)
   04670 Leukocyte transendothelial migration
    8503 (PIK3R3)
   04062 Chemokine signaling pathway
    8503 (PIK3R3)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    8503 (PIK3R3)
   04929 GnRH secretion
    8503 (PIK3R3)
   04915 Estrogen signaling pathway
    8503 (PIK3R3)
   04917 Prolactin signaling pathway
    8503 (PIK3R3)
   04926 Relaxin signaling pathway
    8503 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    8503 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    8503 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    8503 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    8503 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    8503 (PIK3R3)
   04722 Neurotrophin signaling pathway
    8503 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    8503 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    8503 (PIK3R3)
   04380 Osteoclast differentiation
    8503 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    8503 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    8503 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    8503 (PIK3R3)
   05206 MicroRNAs in cancer
    8503 (PIK3R3)
   05205 Proteoglycans in cancer
    8503 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    8503 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    8503 (PIK3R3)
   05203 Viral carcinogenesis
    8503 (PIK3R3)
   05230 Central carbon metabolism in cancer
    8503 (PIK3R3)
   05231 Choline metabolism in cancer
    8503 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    8503 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    8503 (PIK3R3)
   05212 Pancreatic cancer
    8503 (PIK3R3)
   05225 Hepatocellular carcinoma
    8503 (PIK3R3)
   05226 Gastric cancer
    8503 (PIK3R3)
   05214 Glioma
    8503 (PIK3R3)
   05221 Acute myeloid leukemia
    8503 (PIK3R3)
   05220 Chronic myeloid leukemia
    8503 (PIK3R3)
   05218 Melanoma
    8503 (PIK3R3)
   05211 Renal cell carcinoma
    8503 (PIK3R3)
   05215 Prostate cancer
    8503 (PIK3R3)
   05213 Endometrial cancer
    8503 (PIK3R3)
   05224 Breast cancer
    8503 (PIK3R3)
   05222 Small cell lung cancer
    8503 (PIK3R3)
   05223 Non-small cell lung cancer
    8503 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    8503 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    8503 (PIK3R3)
   05161 Hepatitis B
    8503 (PIK3R3)
   05160 Hepatitis C
    8503 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    8503 (PIK3R3)
   05164 Influenza A
    8503 (PIK3R3)
   05162 Measles
    8503 (PIK3R3)
   05163 Human cytomegalovirus infection
    8503 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    8503 (PIK3R3)
   05169 Epstein-Barr virus infection
    8503 (PIK3R3)
   05165 Human papillomavirus infection
    8503 (PIK3R3)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    8503 (PIK3R3)
   05135 Yersinia infection
    8503 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    8503 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    8503 (PIK3R3)
   05142 Chagas disease
    8503 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    8503 (PIK3R3)
   05017 Spinocerebellar ataxia
    8503 (PIK3R3)
   05020 Prion disease
    8503 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    8503 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    8503 (PIK3R3)
   05415 Diabetic cardiomyopathy
    8503 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    8503 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    8503 (PIK3R3)
   04931 Insulin resistance
    8503 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    8503 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    8503 (PIK3R3)
   01524 Platinum drug resistance
    8503 (PIK3R3)
   01522 Endocrine resistance
    8503 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8503 (PIK3R3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    8503 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Transcrip_act Exonuc_VII_L Bap31_Bap29_C
Other DBs
NCBI-GeneID: 8503
NCBI-ProteinID: NP_001107644
OMIM: 606076
HGNC: 8981
Ensembl: ENSG00000117461
UniProt: Q92569 Q8N381
LinkDB
Position
1:complement(46040140..46174901)
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVPNGMKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagcagttccaaatggaatgaaggacagttctgtttctctt
caggatgcagaatggtactggggggatatttcaagggaggaggtaaatgacaaattgcgg
gatatgccagatgggaccttcttggtccgagatgcctcaacaaaaatgcagggagattat
actttgactttgcggaagggaggcaataataagttaataaagatctatcaccgggatggt
aaatatggcttttctgatcctctgacatttaattccgtggtggagctcattaaccactat
caccatgaatctcttgctcagtacaatcccaaacttgatgtgaagctgatgtacccagtg
tccagataccaacaggatcagttggtaaaagaagataatattgatgcagtaggtaaaaaa
ctgcaagaataccactctcagtatcaggagaagagtaaagagtatgataggctgtatgaa
gaatatactagaacatcccaggaaatacagatgaagaggactgcaatagaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcacacacaagaacaacatagcaaagaatat
attgagcgatttcgcagagaggggaatgaaaaggagattgaacgaattatgatgaattat
gataaattgaaatcacgtctgggtgagattcatgatagcaaaatgcgtctagagcaggat
ttgaagaatcaagctttggacaaccgagaaatagataaaaaaatgaatagcatcaaacct
gacctgatccagctgcgaaagatccgagatcaacaccttgtatggctcaatcacaaagga
gtgagacagaaacgcctgaatgtctggctgggaattaagaatgaggatgctgatgagaac
tattttatcaatgaggaagatgaaaacctgccccattatgatgagaaaacctggtttgtt
gaggatatcaatcgagtacaagcagaggacttgctttatgggaaacctgatggtgcattc
ttaattcgtgagagtagcaagaaaggatgctatgcttgctctgtggtggccgatggggaa
gtgaagcactgtgtgatctacagcactgctcggggctatggctttgcagagccctacaac
ctgtacagctctctgaaggagctagtgctccattaccagcagacatccttggttcagcac
aacgactccctcaacgtcaggcttgcctaccctgttcatgcacagatgccctcgctttgc
agataa

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